Synthesis of rare sugars with L-fuculose-1-phosphate aldolase (FucA) from Thermus thermophilus HB8

被引：39

作者：

Li, Zijie ^{[1
,2
,3
]}

Cai, Li ^{[1
]}

Qi, Qingsheng ^{[2
,3
]}

Styslinger, Thomas J. ^{[1
]}

Zhao, Guohui ^{[1
]}

Wang, Peng George ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA

[2] Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250100, Shandong, Peoples R China

[3] Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Shandong, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 17期

关键词：

Aldolase; Rare sugar; Synthesis; FucA; C BOND FORMATION; D-TAGATOSE; 3-EPIMERASE; ONE-POT SYNTHESIS; D-PSICOSE; D-FRUCTOSE; DIHYDROXYACETONE PHOSPHATE; FUCULOSE; 1-PHOSPHATE; ORGANIC-SYNTHESIS; L-FUCOSE; ENZYMES;

D O I：

10.1016/j.bmcl.2011.03.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report herein a one-pot four-enzyme approach for the synthesis of the rare sugars D-psicose, D-sorbose, L-tagatose, and L-fructose with aldolase FucA from a thermophilic source (Thermus thermophilus HB8). Importantly, the cheap starting material DL-GP (DL-glycerol 3-phosphate), was used to significantly reduce the synthetic cost. (c) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5084 / 5087

页数：4

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