Lactylation driven by lactate metabolism in the disc accelerates intervertebral disc degeneration: A hypothesis

被引:1
|
作者
Cheng, Chuan [1 ]
Xu, Zhiqiang [2 ]
Yang, Cao [2 ]
Wu, Xinghuo [2 ]
机构
[1] Huazhong Univ Sci & Technol, Wuhan Union Hosp, Tongji Med Coll, Comp Management Ctr, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Wuhan Union Hosp, Tongji Med Coll, Dept Orthopaed Surg, Wuhan 430022, Hubei, Peoples R China
基金
美国国家科学基金会;
关键词
Lactylation; Histone; Post-translational; Nucleus pulposus; Glycolysis; NUCLEUS PULPOSUS CELLS; AUTOPHAGY; APOPTOSIS; PH; PROMOTES; ETIOLOGY; LYSINE;
D O I
10.1016/j.mehy.2021.110758
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The imbalance of intracellular homeostasis is closely related to intervertebral disc degeneration (IDD). Lactate, the final product of glycolysis, is a potential biomarker of IDD. The disorder of lactate transport and metabolism can significantly increase the concentration of lactate and affect the acidity of extracellular matrix, which is the main cause of the acidic environment in the disc and IDD. The metabolic function of lactate has been studied in depth, but its non-metabolic function is still unclear. The newly discovered modification of histone lactylation provides a new idea for the mechanism of IDD. The production and accumulation of lactate results in increased modification level of histone lactylation in intervertebral disc. Furthermore, it will affect genome-level transcriptional regulation, regulate the function and fate of nucleus pulposus cells, and lead to the occurrence and development of intervertebral disc degeneration. During the process of IDD, lactate production and histone lactylation modification may be an important regulatory mechanism of IDD, which is worthy of further investigation.
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页数:4
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