Klotho Prevents Translocation of NFκB

Klotho protein is a beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. Two molecules are produced by the Klotho gene, a membrane bound form and a circulating form. This protein is recognized as an antiaging gene with pleiotropic functions. The activation of cellular systems is associated with the pathogenesis of several chronic and degenerative diseases associated with an inflammatory state. Inflammation is characterized by an activation of NF kappa B. Klotho suppresses nuclear factor NF kappa B activation and the subsequent transcription of proinflammatory genes. This review focuses on the current understanding of Klotho protein function and its relationship with NF kappa B regulation, emphasizing its potential involvement in the pathophysiologic process.