Palladium/Lewis Acid Co-catalyzed Divergent Asymmetric Ring-Opening Reactions of Azabenzonorbornadienes with Alcohols

被引：53

作者：

Yang, Fan ^{[1
]}

Chen, Jingchao ^{[1
]}

Xu, Jianbin ^{[1
]}

Ma, Fujie ^{[1
]}

Zhou, Yongyun ^{[1
]}

Shinde, Madhuri Vikas ^{[1
]}

Fan, Baomin ^{[1
]}

机构：

[1] Yunnan Minzu Univ, YMU HKBU Joint Lab Tradit Nat Med, Kunming 650500, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 19期

基金：

中国国家自然科学基金;

关键词：

AZABICYCLIC ALKENES; OXABICYCLIC ALKENES; TRANSFER HYDROGENATION; ALPHA; BETA-UNSATURATED KETONES; AMINE NUCLEOPHILES; COMPLEXES; OXABENZONORBORNADIENES; (+)-HOMOCHELIDONINE; ALKALOIDS; PROGRESS;

D O I：

10.1021/acs.orglett.6b02300

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By fine tuning the combinations of chiral palladium catalysts and Lewis acids, both the additional and reductive asymmetric ring-opening reactions of azabenzonorbornadienes with alcohols were accomplished with good chemoselectivity, regioselectivity, and enantioselectivity. It was proven that the reductive ring-opening products were generated through a transfer hydrogenation process with alcohols as hydrogen source.

引用

页码：4832 / 4835

页数：4

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