Evaluation of genetic and developmental toxicity of surfactin C from Bacillus subtilis BC1212

被引：20

作者：

Hwang, Youn-Hwan ^{[1
]}

Park, Byung-Kwon ^{[2
]}

Lim, Jong-Hwan ^{[3
]}

Kim, Myoung-Seok ^{[1
]}

Song, In-Bae ^{[1
]}

Park, Seung-Chun ^{[4
]}

Yun, Hyo-In ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Vet Med, Taejon 305764, South Korea

[2] JUNJINBIO, Taegu 70230, South Korea

[3] B&C Biopharm, Yongin 449863, Gyeonggi Do, South Korea

[4] Kyungpook Natl Univ, Coll Vet Med, Taegu 702701, South Korea

来源：

JOURNAL OF HEALTH SCIENCE | 2008年 / 54卷 / 01期

关键词：

surfactin C; genotoxicity; developmental toxicity; no-observed-adverse-effect level;

D O I：

10.1248/jhs.54.101

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Surfactin C is a biosurfactant produced by Bacillus subtilis from Korean soybean paste. Surfactin C is known to have several therapeutic effects including anti-inflammatory, fibrinolytic, and thrombolytic activities. However, there is little information concerning its safety. In this study, we evaluated the genetic and developmental toxicity of surfactin C. Bacterial reverse mutation and rodent micronucleus assays were performed to determine its genotoxic potentials. Surfactin C at 0, 125, 250, and 500 mg/kg of body weight/day was administered orally to pregnant ICR mice during the period of major organogenesis. There was no genetic toxicity related to surfactin C treatment in in vitro and in vivo systems. In the developmental study, surfactin C did not demonstrate maternal toxicity, fetotoxicity, and teratogenicity, and hence the no observed effect level was concluded 500 mg/kg per day in ICR mice.

引用

页码：101 / 106

页数：6

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