Platelets as Central Mediators of Systemic Inflammatory Responses

被引：51

作者：

Smith, Tammy L. ^{[3
]}

Weyrich, Andrew S. ^{[1
,2
,3
]}

机构：

[1] Univ Utah, Eccles Inst Human Genet, Program Mol Med, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA

[3] Univ Utah, Dept Microbiol & Immunol, Salt Lake City, UT 84112 USA

来源：

THROMBOSIS RESEARCH | 2011年 / 127卷 / 05期

关键词：

NEUTROPHIL EXTRACELLULAR TRAPS; ACTIVATED HUMAN PLATELETS; TISSUE FACTOR; ANUCLEATE PLATELETS; P-SELECTIN; EXPRESSION; SEPSIS; LIPOPOLYSACCHARIDE; THROMBOCYTOPENIA; AGGREGATION;

D O I：

10.1016/j.thromres.2010.10.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic inflammatory responses are associated with high morbidity and mortality and represent a diverse and clinically challenging group of diseases. Platelets are increasingly linked to inflammation, in addition to their well-known roles in hemostasis and thrombosis. There is agreement that traditional functions of platelets, including adherence, aggregation, and secretion of preformed mediators, contribute to systemic inflammatory responses. However, emerging evidence indicates that platelets function in non-traditional ways. In this review, we focus on new functions of platelets that may be involved in the host response to infection. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：391 / 394

页数：4

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