Synthesis, crystal structure, 1H, 13C and 15N NMR studies, and biological evaluation of a new amidrazone-derived Au(III) complex

被引：2

作者：

Paprocka, Renata ^{[1
]}

Modzelewska-Banachiewicz, Bozena ^{[1
]}

Pazderski, Leszek ^{[2
]}

Mazur, Liliana ^{[3
]}

Kutkowska, Jolanta ^{[4
]}

Niedzielska, Dania ^{[2
]}

Psurski, Mateusz ^{[5
]}

Wietrzyk, Joanna ^{[5
]}

Saczewski, Jaroslaw ^{[6
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Dept Organ Chem, Fac Pharm, Jurasza 2, PL-85089 Bydgoszcz, Poland

[2] Nicolaus Copernicus Univ Torun, Dept Analyt Chem & Appl Spect, Fac Chem, Gagarina 7, PL-87100 Torun, Poland

[3] Marie Curie Sklodowska Univ, Dept Gen & Coordinat Chem, Fac Chem, M Curie Sklodowska Sq 2, PL-20031 Lublin, Poland

[4] Marie Curie Sklodowska Univ, Dept Genet & Microbiol, Akad 19, PL-20033 Lublin, Poland

[5] Polish Acad Sci, Inst Immunol & Expt Therapy, R Weigla 12, PL-53114 Wroclaw, Poland

[6] Med Univ Gdansk, Dept Organ Chem, Fac Pharm, Hallera 107, PL-80416 Gdansk, Poland

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2019年 / 1176卷

关键词：

Amidrazone; Au(III) complex; Single crystal X-ray studies; N-15; NMR; Antibacterial; Antiproliferative; PT(II) CHLORIDE COMPLEXES; N BOND FORMATION; COORDINATION SHIFTS; X-RAY; GOLD(III) COMPLEXES; CYCLOAURATED COMPLEXES; COPPER(II) COMPLEX; ANTICANCER AGENTS; CHEMICAL-SHIFTS; GOLD COMPLEXES;

D O I：

10.1016/j.molstruc.2018.07.076

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new Au(III) complex was synthesized from an amidrazone derivative and HAuCl4. Cyclization of amidrazone moiety lead to the 1,2,4-triazolo[1,5a]pyridine ring system, followed by Au(III) chelation. The crystal and molecular structure of the final compound was studied by single crystal X-ray diffraction as well as by( 1)H -C-13 and H-1 -(15) N HMQC- and HMBC-NMR spectroscopy, which resulted in the assignment of all detected signals. This species was tested in vitro as an antibacterial and antiproliferative agent. It exhibited good antibacterial activity against Staphylococcus aureus and was proved to be more potent than amoxicillin against Bacillus subtilis and the drug resistant strain of Klebsiella pneumoniae. In contrast, its antiproliferative properties against cancer cell lines A549, HT-29, MV-4-11 and MCF-7 were relatively low. (C) 2018 Published by Elsevier B.V.

引用

页码：357 / 365

页数：9

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