Time course of the triglyceride glucose index accumulation with the risk of cardiovascular disease and all-cause mortality

被引：12

作者：

Tian, Xue ^{[1
,2
]}

Chen, Shuohua ^{[3
]}

Zhang, Yijun ^{[4
,5
]}

Zhang, Xiaoli ^{[4
,5
]}

Xu, Qin ^{[4
,5
]}

Wang, Penglian ^{[4
,5
]}

Wu, Shouling ^{[3
]}

Wang, Anxin ^{[4
,5
]}

Luo, Yanxia ^{[1
,2
]}

机构：

[1] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, 10 Xitoutiao, Beijing 100069, Peoples R China

[2] Beijing Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China

[3] North China Univ Sci & Technol, Kailuan Hosp, Dept Cardiol, 57 Xinhua East Rd, Tangshan 063000, Peoples R China

[4] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China

[5] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, 119 South 4th Ring West Rd, Beijing 100070, Peoples R China

来源：

CARDIOVASCULAR DIABETOLOGY | 2022年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Cardiovascular disease; All-cause mortality; Triglyceride-glucose index; Time course analysis; Cohort study; INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION; HYPERTENSION; ONSET; AGE;

D O I：

10.1186/s12933-022-01617-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Future risk of cardiovascular disease (CVD) and mortality is associated with cumulative amount TyG index (cumTyG) exposure, while whether time course of TyG accumulation modulates the risk remains unclear. This study sought to examine the associations of cumTyG index accumulation time course with the risk of CVD and all-cause mortality. Methods We enrolled 51,734 participants free of CVD and underwent three examinations at year 2006, 2008, and 2010. CumTyG from baseline to the third examination was calculated. Time course of cumTyG accumulation was calculated as the slope of TyG versus time from 2006 to 2010, or as splinting the overall TyG index accumulation into early (cumTyG(06 - 08)) and late accumulation (cumTyG(08 - 10)). Participants were categorized by the combination of cumTyG < or >= median (34.44 x years) and a negative or positive TyG slope. Results During a median follow-up of 9.04 years, we identified 3,602 incident CVD cases and 3,165 deaths. The risk of CVD and all-cause mortality increased with decreased TyG slope, the corresponding adjusted hazard ratio (aHR) with 95% confidence interval (CI) was 1.11 (1.04-1.19) and 1.18 (1.10-1.26) for patients with a negative TyG slope, respectively. Consistently, a later accumulation of TyG index was not associated with the risk of CVD and all-cause mortality after adjustment for an early accumulation. When considering the combination of cumTyG index and time course, participants with a cumTyG >= median and a negative TyG slope had elevated risk of CVD (aHR, 1.37; 95% CI, 1.24-1.51) and all-cause mortality (aHR, 1.28; 95% CI, 1.15-1.43). Additionally, the association was more prominent in young adults. Conclusion Early TyG index accumulation resulted in a greater risk of CVD and all-cause mortality than later TyG later accumulation with the same overall cumulative exposure, emphasizing the importance of optimal TyG index control earlier in life.

引用

页数：12