Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research

被引：298
作者：
Spencer, Jeremy P. E. [1 ]
El Mohsen, Manal M. Abd [1 ]
Minihane, Ann-Marie [1 ]
Mathers, John C. [2 ]
机构：
[1] Univ Reading, Sch Chem Food & Pharm, Reading RG6 6AP, Berks, England
[2] Univ Newcastle, Sch Clin Med Sci, Human Nutr Res Ctr, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
BRITISH JOURNAL OF NUTRITION | 2008年 / 99卷 / 01期
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
polyphenol; flavonoid; phenolic acid; biomarker; human subjects; metabolism;
D O I：
10.1017/S0007114507798938
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
In order to establish firm evidence for the health effects of dietary polyphenol consumption, it is essential to have quantitative information regarding their dietary intake. The usefulness of the current methods, which rely mainly on the assessment of polyphenol intake using food records and food composition tables, is limited as they fail to assess total intake accurately. This review highlights the problems associated with such methods with regard to polyphenol-intake predictions. We suggest that the development of biological biomarkers, measured in both blood and urine, are essential for making accurate estimates of polyphenol intake. However, the relationship between dietary intakes and nutritional biomarkers are often highly complex. This review identifies the criteria that must be considered in the development of such biomarkers. In addition, we provide an assessment of the limited number of potential biomarkers of polyphenol intake currently available.
引用
收藏
页码：12 / 22
页数：11
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