C-type lectins in immunity: recent developments

被引：366

作者：

Dambuza, Ivy M. ^{[1
]}

Brown, Gordon D. ^{[1
]}

机构：

[1] Univ Aberdeen, Inst Med Sci, Div Appl Med, Aberdeen Fungal Grp,Immun Infect & Inflammat Prog, Aberdeen AB25 2ZD, Scotland

来源：

CURRENT OPINION IN IMMUNOLOGY | 2015年 / 32卷

基金：

英国惠康基金;

关键词：

HOUSE-DUST MITE; DENDRITIC CELL-RECEPTOR; FUNGAL BETA-GLUCANS; HOST-DEFENSE; INNATE IMMUNITY; DECTIN-2; MINCLE; DNGR-1; CARD9; INFLAMMATION;

D O I：

10.1016/j.coi.2014.12.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

C-type lectin receptors (CLRs) comprise a large superfamily of proteins, which recognise a diverse range of ligands, and are defined by the presence of at least one C-type lectin-like domain (CTLD). Of particular interest are the single extracellular CTLD-containing receptors of the 'Dectin-1' and 'Dectin-2' clusters, which associate with signalling adaptors or possess integral intracellular signalling domains. These CLRs have traditionally been associated with the recognition of fungi, but recent discoveries have revealed diverse and unexpected functions. In this review, we describe their newly identified roles in anti-microbial host defence, homeostasis, autoimmunity, allergy and their functions in the recognition and response to dead and cancerous cells.

引用

页码：21 / 27

页数：7

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