Peptide functionalized targeting liposomes: for nanoscale drug delivery towards angiogenesis

被引：13

作者：

Han, Qiuju ^{[1
,2
]}

Jia, Xiangqian ^{[1
,2
]}

Qian, Yixia ^{[2
,3
]}

Wang, Zihua ^{[2
]}

Yang, Shu ^{[2
]}

Jia, Yunhong ^{[1
]}

Wang, Weizhi ^{[2
]}

Hu, Zhiyuan ^{[2
]}

机构：

[1] Jinzhou Med Univ, Jinzhou 121001, Liaoning, Peoples R China

[2] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 44期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

TUMOR MICROENVIRONMENT; CANCER-THERAPY; MICROARRAY; VEGFR2; SYSTEM; PROBES; CELLS; NANOPARTICLES; NANODRUG; HER2;

D O I：

10.1039/c6tb01823h

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A novel affinity peptide S1 (LIDHEWKENYFPLSF) was screened out via a "one bead one compound'' (OBOC) approach on a microarray device. It was identified that S1 could specifically recognize and bind to vascular endothelial growth factor receptor 2 (VEGFR2), which is an angiogenesis biomarker. Moreover, S1-functionalized liposomes (S1-LS) could achieve efficient nanoscale drug delivery under the conditions of VEGFR2-overexpression in vitro and in vivo. It was demonstrated that S1-LS would be a promising VEGFR2-targeting drug delivery system.

引用

页码：7087 / 7091

页数：5

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