Peptide functionalized targeting liposomes: for nanoscale drug delivery towards angiogenesis

被引：13
|
作者：
Han, Qiuju [1 ,2 ]
Jia, Xiangqian [1 ,2 ]
Qian, Yixia [2 ,3 ]
Wang, Zihua [2 ]
Yang, Shu [2 ]
Jia, Yunhong [1 ]
Wang, Weizhi [2 ]
Hu, Zhiyuan [2 ]
机构：
[1] Jinzhou Med Univ, Jinzhou 121001, Liaoning, Peoples R China
[2] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 44期
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
TUMOR MICROENVIRONMENT; CANCER-THERAPY; MICROARRAY; VEGFR2; SYSTEM; PROBES; CELLS; NANOPARTICLES; NANODRUG; HER2;
D O I：
10.1039/c6tb01823h
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A novel affinity peptide S1 (LIDHEWKENYFPLSF) was screened out via a "one bead one compound'' (OBOC) approach on a microarray device. It was identified that S1 could specifically recognize and bind to vascular endothelial growth factor receptor 2 (VEGFR2), which is an angiogenesis biomarker. Moreover, S1-functionalized liposomes (S1-LS) could achieve efficient nanoscale drug delivery under the conditions of VEGFR2-overexpression in vitro and in vivo. It was demonstrated that S1-LS would be a promising VEGFR2-targeting drug delivery system.
引用
收藏
页码：7087 / 7091
页数：5
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