Alternative splicing in mesenchymal stem cell differentiation

被引：35

作者：

Park, Jung Woo ^{[1
,2
]}

Fu, Siyi ^{[1
,2
]}

Huang, Borong ^{[1
,2
]}

Xu, Ren-He ^{[1
,2
]}

机构：

[1] Univ Macau, Ctr Reprod Dev & Aging, Fac Hlth Sci, Macau, Peoples R China

[2] Univ Macau, Inst Translat Med, Fac Hlth Sci, Macau, Peoples R China

来源：

STEM CELLS | 2020年 / 38卷 / 10期

关键词：

adipogenic; alternative splicing; chondrogenic; ESC differentiation; mesenchymal stem cells; MSC differentiation; neural differentiation; osteogenic; RNA-binding proteins; MESSENGER-RNA; ISOFORM EXPRESSION; TRANSCRIPTION; PROTEIN; ROLES; SOX9; GENE; CHONDROGENESIS; IDENTIFICATION; REGULATOR;

D O I：

10.1002/stem.3248

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The differentiation and maturation of mesenchymal stem cells (MSCs) to mesodermal and other lineages are known to be controlled by various extrinsic and intrinsic signals. The dysregulation of the MSC differentiation balance has been linked to several pathophysiological conditions, including obesity and osteoporosis. Previous research of the molecular mechanisms governing MSC differentiation has mostly focused on transcriptional regulation. However, recent findings are revealing the underrated role of alternative splicing (AS) in MSC differentiation and functions. In this review, we discuss recent progress in elucidating the regulatory roles of AS in MSC differentiation. We catalogue and highlight the key AS events that modulate MSC differentiation to major osteocytes, chondrocytes, and adipocytes, and discuss the regulatory mechanisms by which AS is regulated.

引用

页码：1229 / 1240

页数：12

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