Poly(L-glutamic acid)-based star-block copolymers as pH-responsive nanocarriers for cationic drugs

被引：39

作者：

Huang, Huihong ^{[1
]}

Li, Jiayan ^{[1
]}

Liao, Lihui ^{[1
]}

Li, Jinhu ^{[1
]}

Wu, Lixin ^{[1
]}

Dong, Chaoke ^{[1
]}

Lai, Peibao ^{[1
]}

Liu, Daojun ^{[1
]}

机构：

[1] Shantou Univ, Coll Med, Shantou 515041, Peoples R China

来源：

EUROPEAN POLYMER JOURNAL | 2012年 / 48卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Poly(L-glutamic acid); Star-block copolymer; Drug delivery system; pH-responsive; DENDRITIC MULTISHELL ARCHITECTURES; POLYAMIDOAMINE DENDRIMERS; POLY(ETHYLENE GLYCOL); UNIMOLECULAR MICELLES; DELIVERY APPLICATIONS; MICELLIZATION; POLYMERS; CARRIERS; COPOLYPEPTIDES; ENCAPSULATION;

D O I：

10.1016/j.eurpolymj.2012.01.011

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Star-block copolymers PEI-g-(PLG-b-PEG), which consist of a hyperbranched polyethylenimine (PEI) core, a poly(t-glutamic acid) (PLC) inner shell, and a poly(ethylene glycol) (PEG) outer shell, were synthesised and evaluated as nanocarriers for cationic drugs. The synthesised star-block copolymers were characterised by H-1 NMR, gel permeation chromatography (GPC), dynamic light scattering (DES), and transmission electron microscopy (TEM). Crystal violet (CV), as a model cationic dye, and doxorubicin hydrochloride (DOX), as a model anticancer drug, could be efficiently entrapped by the synthesised star-block copolymers at physiological pH as a result of electrostatic interactions between the cationic guest molecules and the negatively charged PLC segments in the PEI-g-(PLG-b-PEG) host. The drug-polymer complexes showed relatively high temporal stability at physiological pH and sustained release of the encapsulated drugs was observed. The entrapped model compounds demonstrated accelerated release as the pH was gradually decreased. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：696 / 704

页数：9

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