The Protective Effects of Astaxanthin on the OVA-Induced Asthma Mice Model

被引:37
作者
Hwang, Yun-Ho [1 ]
Hong, Seong-Gyeol [1 ]
Mun, Seul-Ki [1 ]
Kim, Su-Jin [1 ]
Lee, Sung-Ju [1 ]
Kim, Jong-Jin [2 ]
Kang, Kyung-Yun [3 ]
Yee, Sung-Tae [1 ]
机构
[1] Sunchon Natl Univ, Coll Pharm, 255 Jungangno, Sunchon 540950, South Korea
[2] Agcy Sci Technol & Res, Singapore Bioimaging Consortium, 11 Biopolis Way,02-02 Helios, Singapore 138667, Singapore
[3] Suncheon Res Ctr Nat Med, Sunchon 540950, South Korea
关键词
asthma; airway hyperresponsiveness (AHR); helper T cells (Th cells); astaxanthin; AIRWAY HYPERRESPONSIVENESS; INTERFERON-GAMMA; GENE-EXPRESSION; T-CELLS; INFLAMMATION; ACTIVATION; PATHOGENESIS; DISEASE; INJURY;
D O I
10.3390/molecules22112019
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although astaxanthin has a variety of biological activities such as anti-oxidant effects, inhibitory effects on skin deterioration and anti-inflammatory effects, its effect on asthma has not been studied. In this paper, the inhibitory effect of astaxanthin on airway inflammation in a mouse model of ovalbumin (OVA)-induced asthma was investigated. We evaluated the number of total cells, Th1/2 mediated inflammatory cytokines in bronchoalveolar lavage fluid (BALF) and airway hyperresponsiveness as well as histological structure. The level of total IgE, IgG1, IgG2a, OVA-specific IgG1, and OVA-specific IgG2a were also examined. The oral administration of 50 mg/mL astaxanthin inhibited the respiratory system resistance, elastance, newtonian resistance, tissue damping, and tissue elastance. Also, astaxanthin suppressed the total cell number, IL-4, and IL-5, and increased the IFN- in the BALF. In the sera, total IgE, IgG1, and OVA-specific IgG1 were reduced by astaxanthin exposure and IgG2a and OVA-specific IgG2a were enhanced via oral administration of astaxanthin. Infiltration of inflammatory cells in the lung, production of mucus, lung fibrosis, and expression of caspase-1 or caspase-3 were suppressed in OVA-induced asthmatic animal treated with astaxanthin. These results suggest that astaxanthin may have therapeutic potential for treating asthma via inhibiting Th2-mediated cytokine and enhancing Th1-mediated cytokine.
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页数:11
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