Critical examination of Fe8 as a contrast agent for magnetic resonance imaging

被引：9
作者：
Isaacman, S
Kumar, R
del Barco, E
Kent, AD
Canary, JW
Jerschow, A
机构：
[1] NYU, Dept Chem, New York, NY 10003 USA
[2] NYU, Dept Phys, New York, NY 10003 USA
来源：
POLYHEDRON | 2005年 / 24卷 / 16-17期
关键词：
single-molecule magnet; magnetic resonance imaging; supperparamagnet; relaxation; contrast agent;
D O I：
10.1016/j.poly.2005.03.138
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The compound Fe-8 (C36H120O23N18Fe8Br8) was examined for its potential as a contrast agent for magnetic resonance imaging. The compound was prepared, isolated, and shown to exhibit superparamagnetism (S = 10). The structure of Fe-8 in aqueous solution was probed by several NMR techniques. Relaxivity of aqueous Solutions of Fe-8 as well as that of comparison compounds FeCl3, FeCl3(tacn) (tacn = 1,4,7-triazacyclononane), and Gd(DTPA) (DTPA = diethylenetriamine pentaacetic acid) were determined by T-1 and T-2 inversion recovery and CPMG sequences. In contrast to a previous report, the relaxivity of Fe-8 solutions was found to be weak compared to Gd(DTPA). However, ail interesting dependence upon pH was observed. The influence of environmental factors oil relaxivity is of interest in the burgeoning field of molecular imaging. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：2691 / 2694
页数：4
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