Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

被引：52

作者：

Buckheit, Robert W., III ^{[1
]}

Allen, Tracy G. ^{[1
]}

Alme, Angela ^{[1
]}

Salgado, Maria ^{[1
]}

O'Connell, Karen A. ^{[1
]}

Huculak, Sarah ^{[1
]}

Falade-Nwulia, Oluwaseun ^{[1
]}

Williams, Thomas M. ^{[2
,3
]}

Gallant, Joel E. ^{[1
]}

Siliciano, Robert F. ^{[1
,4
]}

Blankson, Joel N. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 USA

[3] Univ New Mexico, Tricore Reference Labs, Albuquerque, NM 87131 USA

[4] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA

来源：

NATURE COMMUNICATIONS | 2012年 / 3卷

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; CD4(+) T-CELLS; LONG-TERM NONPROGRESSORS; ELITE SUPPRESSORS; ESCAPE MUTATIONS; NEF GENE; INFECTION; GAG; CAPACITY; EVOLUTION;

D O I：

10.1038/ncomms1697

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Viremic controllers and elite controllers/ suppressors maintain control over HIV-1 replication. Some studies have suggested that control is a result of infection with a defective viral strain, while others suggested host immune factors have a key role. Here we document two HIV-1 transmission pairs: one consisting of a patient with progressive disease and an individual who became an elite suppressor, and the second consisting of a patient with progressive disease and a viremic controller. In contrast to another elite suppressor transmission pair, virus isolated from all patients was fully competent. These data suggest that some viremic controllers and elite suppressors are infected with HIV-1 isolates that replicate vigorously in vitro and are able to cause progressive disease in vivo. These data suggest that host factors have a dominant role in the control of HIV-1 infection, thus it may be possible to control fully pathogenic HIV-1 isolates with therapeutic vaccination.

引用

页数：10

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