Immunomodulation and antiangiogenesis in cancer therapy. From basic to clinical research

被引：0

作者：

Graciela Scharovsky, O. ^{[1
]}

Matar, Pablo ^{[1
,2
]}

Rozados, Viviana R. ^{[1
]}

Rico, Maria J. ^{[1
]}

Zacarias Fluck, Mariano F. ^{[1
]}

Mainetti, Leandro E. ^{[1
]}

Fernandez Zenobi, M. Virginia ^{[1
]}

Roggero, Eduardo A. ^{[1
]}

Gervasoni, Silvia I. ^{[1
]}

Rossa, Ana ^{[1
]}

Perroud, Herman A. ^{[1
]}

Sanchez, Andrea M. ^{[1
]}

Celoria, Guillermo C. ^{[1
]}

Font, Maria T. ^{[1
]}

机构：

[1] Univ Nacl Rosario, Fac Ciencias Med, Inst Genet Expt, RA-2002 Rosario, Santa Fe, Argentina

[2] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina

来源：

MEDICINA-BUENOS AIRES | 2012年 / 72卷 / 01期

关键词：

immunomodulation; angiogenesis; cancer; cyclophosphamide; celecoxib; LOW-DOSE CYCLOPHOSPHAMIDE; METASTATIC BREAST-CANCER; REGULATORY T-CELLS; RAT LYMPHOMA; METRONOMIC CHEMOTHERAPY; ADOPTIVE IMMUNOTHERAPY; TUMOR ANGIOGENESIS; MYELOID CELLS; BEARING RATS; GROWTH;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunomodulation and antiangiogenesis in cancer therapy. From basic to clinical research. Basic and pre-clinic research in cellular and molecular oncology are the main supports accounting for the advancement in cancer therapeutics. The findings achieved, and their implementation in clinical practice are responsible for the permanent improvement in the treatment of the neoplastic disease. Our present objective is to summarize and discuss the pre-clinical findings in immunomodulation and anti-angiogenesis for the treatment of several types of tumors obtained in our Institute during the last 15 years, and the subsequent translation and application of the acquired experimental knowledge in a Phase I/II Clinical Trial. We present the results and mechanisms of action of antimetastatic immunomodulation with cyclophosphamide, the metronomic chemotherapy with different single drugs and their combinations, and finally the design and preliminary results of a clinical trial with metronomic chemotherapy for patients with advanced breast cancer.

引用

页码：47 / 57

页数：11

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