Marked potentiation of activity of β-lactams against methicillin-resistant Staphylococcus aureus by corilagin

被引：103
|
作者：
Shimizu, M
Shiota, S
Mizushima, T
Ito, H
Hatano, T
Yoshida, T
Tsuchiya, T
机构：
[1] Okayama Univ, Fac Pharmaceut Sci, Dept Microbiol, Okayama 7008530, Japan
[2] Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Okayama 7008530, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 11期
关键词：
D O I：
10.1128/AAC.45.11.3198-3201.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We found that an extract of Aretostaphylos uva-ursi markedly reduced the MICs of beta -lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various beta -lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.
引用
收藏
页码：3198 / 3201
页数：4
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