Microbial-induced immunomodulation by targeting the NF-κB system

被引：23

作者：

Neish, Andrew S. ^{[2
]}

Naumann, Michael ^{[1
]}

机构：

[1] Otto Von Guericke Univ, Fac Med, Inst Expt Internal Med, D-39120 Magdeburg, Germany

[2] Emory Univ, Sch Med, Emory Univ Hosp, Atlanta, GA 30322 USA

来源：

TRENDS IN MICROBIOLOGY | 2011年 / 19卷 / 12期

关键词：

INNATE IMMUNE-RESPONSES; UBIQUITIN-CONJUGATING ENZYMES; TOLL-LIKE RECEPTORS; REACTIVE OXYGEN; ALPHA UBIQUITINATION; BACTERIAL PATHOGENS; ACTIVATION; PATHWAY; PROTEIN; INFLAMMATION;

D O I：

10.1016/j.tim.2011.08.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Virtually all eukaryotes have developed defense mechanisms to efficiently counter potential threats from prokaryotic microorganisms; an example is the conserved nuclear factor-kappaB (NF-kappa B) signaling system. However, bacterial pathogens and commensals have in turn evolved highly effective counter mechanisms to modulate this immune regulatory circuit. Modifications in ubiquitin, ubiquitin-like (Ubl) proteins such as neural precursor cell expressed, developmentally down-regulated 8(NEDD8) and other post-translational modifications (PTMs) in the NF-kappa B system represent attractive targets for microbial manipulation. In this review, we describe recent advances in understanding the different strategies that bacteria have evolved to interfere with PTMs in NF-kappa B signal transmission.

引用

页码：596 / 605

页数：10

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