Glycosphingolipid Functions

被引：89

作者：

Lingwood, Clifford A. ^{[1
]}

机构：

[1] Hosp Sick Children Mol Struct & Funct, Res Inst, Toronto, ON M5G 1X8, Canada

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2011年 / 3卷 / 07期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; HEMOLYTIC-UREMIC SYNDROME; GROWTH-FACTOR RECEPTOR; SPHINGOLIPID-STORAGE DISEASES; EMBRYONIC ANTIGEN SSEA-1; SHIGA-LIKE TOXIN; PICK TYPE-C; GALACTOSE-CERAMIDE GALACTOSYLTRANSFERASE; HUMAN-ERYTHROCYTE GLYCOSPHINGOLIPIDS; CELL-SURFACE GLYCOSPHINGOLIPIDS;

D O I：

10.1101/cshperspect.a004788

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The combination of carbohydrate and lipid generates unusual molecules in which the two distinctive halves of the glycoconjugate influence the function of each other. Membrane glycolipids can act as primary receptors for carbohydrate binding proteins to mediate transmembrane signaling despite restriction to the outer bilayer leaflet. The extensive heterogeneity of the lipid moiety plays a significant, but still largely unknown, role in glycosphingolipid function. Potential interplay between glycolipids and their fatty acid isoforms, together with their preferential interaction with cholesterol, generates a complex mechanism for the regulation of their function in cellular physiology.

引用

页码：1 / 26

页数：26

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