A Novel Method for Detecting Duchenne Muscular Dystrophy in Blood Serum of mdx Mice

被引：2

作者：

Ralbovsky, Nicole M. ^{[1
,2
]}

Dey, Paromita ^{[2
]}

Galfano, Andrew ^{[1
]}

Dey, Bijan K. ^{[2
,3
]}

Lednev, Igor K. ^{[1
,2
,3
]}

机构：

[1] SUNY Albany, Dept Chem, 1400 Washington Ave, Albany, NY 12222 USA

[2] SUNY Albany, RNA Inst, 1400 Washington Ave, Albany, NY 12222 USA

[3] SUNY Albany, Dept Biol Sci, 1400 Washington Ave, Albany, NY 12222 USA

来源：

GENES | 2022年 / 13卷 / 08期

关键词：

Raman spectroscopy; chemometrics; early diagnosis; skeletal muscle; Duchenne muscular dystrophy; SKELETAL-MUSCLE DIFFERENTIATION; RAMAN-SPECTROSCOPY; CREATINE-PHOSPHOKINASE; LIGHT-SCATTERING; DIAGNOSTICS;

D O I：

10.3390/genes13081342

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy, typically affecting males in infancy. The disease causes progressive weakness and atrophy of skeletal muscles, with approximately 20,000 new cases diagnosed yearly. Currently, methods for diagnosing DMD are invasive, laborious, and unable to make accurate early detections. While there is no cure for DMD, there are limited treatments available for managing symptoms. As such, there is a crucial unmet need to develop a simple and non-invasive method for accurately detecting DMD as early as possible. Raman spectroscopy with chemometric analysis is shown to have the potential to fill this diagnostic need.

引用

页数：14

共 35 条

[1] The mouse dystrophin muscle promoter/enhancer drives expression of mini-dystrophin in transgenic mdx mice and rescues the dystrophy in these mice [J].

Anderson, Carrie L. ;

De Repentigny, Yves ;

Cifelli, Carlo ;

Marshall, Philip ;

Renaud, Jean-Marc ;

Worton, Ronald G. ;

Kothary, Rashmi .

MOLECULAR THERAPY, 2006, 14 (05) :724-734

[2]

[Anonymous], Muscular dystrophy

[3] Raman Based Molecular Imaging and Analytics: A Magic Bullet for Biomedical Applications!? [J].

Bocklitz, Thomas W. ;

Guo, Shuxia ;

Ryabchykov, Oleg ;

Vogler, Nadine ;

Popp, Juergen .

ANALYTICAL CHEMISTRY, 2016, 88 (01) :133-151

[4] Creatine kinase monitoring in sport medicine [J].

Brancaccio, Paola ;

Maffulli, Nicola ;

Limongelli, Francesco Mario .

BRITISH MEDICAL BULLETIN, 2007, 81-82 :209-230

[5] How to use: creatine kinase [J].

Chakrabarty, Tanmoy ;

Tirupathi, Sandya ;

Thompson, Andrew .

ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION, 2020, 105 (03) :157-163

[6] The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration [J].

Dey, Bijan K. ;

Pfeifer, Karl ;

Dutta, Anindya .

GENES & DEVELOPMENT, 2014, 28 (05) :491-501

[7] miR-26a is required for skeletal muscle differentiation and regeneration in mice [J].

Dey, Bijan K. ;

Gagan, Jeffrey ;

Yan, Zhen ;

Dutta, Anindya .

GENES & DEVELOPMENT, 2012, 26 (19) :2180-2191

[8] Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy [J].

Ellis, David I. ;

Goodacre, Royston .

ANALYST, 2006, 131 (08) :875-885

[9]

Ferraro J. R., 2003, INTRO RAMAN SPECTROS, DOI DOI 10.1016/B978-012254105-6/50004-4

[10] Raman spectroscopy for medical diagnostics - From in-vitro biofluid assays to in-vivo cancer detection [J].

Kong, Kenny ;

Kendall, Catherine ;

Stone, Nicholas ;

Notingher, Ioan .

ADVANCED DRUG DELIVERY REVIEWS, 2015, 89 :121-134

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