The Potential of Antimicrobial Peptides as Biocides

被引：133

作者：

Laverty, Garry ^{[1
]}

Gorman, Sean P. ^{[2
]}

Gilmore, Brendan F. ^{[2
]}

机构：

[1] Ward Biotech Ltd, Glasdrummann, Milltown, Monaghan, Ireland

[2] Queens Univ Belfast, Sch Pharm, Biomat Res Grp, Ctr Med Biol, Belfast BT9 7BL, Antrim, North Ireland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2011年 / 12卷 / 10期

关键词：

antimicrobial; peptides; biocides; IN-VITRO ACTIVITY; RESISTANT PSEUDOMONAS-AERUGINOSA; HOST-DEFENSE PEPTIDES; ESCHERICHIA-COLI; CANDIDA-ALBICANS; ANTIBACTERIAL PEPTIDES; POLYMYXIN-B; FATTY-ACIDS; MACROMOLECULAR-SYNTHESIS; STAPHYLOCOCCUS-AUREUS;

D O I：

10.3390/ijms12106566

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobial peptides constitute a diverse class of naturally occurring antimicrobial molecules which have activity against a wide range of pathogenic microorganisms. Antimicrobial peptides are exciting leads in the development of novel biocidal agents at a time when classical antibiotics are under intense pressure from emerging resistance, and the global industry in antibiotic research and development stagnates. This review will examine the potential of antimicrobial peptides, both natural and synthetic, as novel biocidal agents in the battle against multi-drug resistant pathogen infections.

引用

页码：6566 / 6596

页数：31

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