Near-Infrared Dyes: Probe Development and Applications in Optical Molecular Imaging

被引：62
|
作者：
Nolting, Donald D. [1 ]
Gore, John C. [1 ]
Pham, Wellington [1 ]
机构：
[1] Vanderbilt Univ, Inst Imaging Sci, Med Ctr N, Nashville, TN 37232 USA
来源：
CURRENT ORGANIC SYNTHESIS | 2011年 / 8卷 / 04期
关键词：
Cyanine; fluorescence; FRET; imaging; optical; probe; rhodamine; MATRIX METALLOPROTEINASE-7 ACTIVITY; RED FLUORESCENT PEPTIDE; IN-VIVO; BACTERIAL-INFECTION; SUCCINIMIDYL ESTERS; LABELING REAGENTS; MEMBRANE-PERMEANT; PROTEASE ACTIVITY; HEMICYANINE DYES; CONTRAST AGENTS;
D O I：
10.2174/157017911796117223
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The recent emergence of optical imaging has brought forth a unique challenge for chemists: development of new biocompatible dyes that fluoresce in the near-infrared (NIR) region for optimal use in biomedical applications. This review describes the synthesis of NIR dyes and the design of probes capable of noninvasively imaging molecular events in small animal models.
引用
收藏
页码：521 / 534
页数：14
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