Bilateral Atypical Femur Fractures After Denosumab in a Bisphosphonate Naive Patient: A Case Report

被引：8

作者：

Goh, Jeremy Keng Meng ^{[1
]}

Koh, Joyce Suang Bee ^{[1
]}

Ng, Alvin Choong Meng ^{[2
]}

Png, Meng Ai ^{[3
]}

Sen Howe, Tet ^{[1
]}

机构：

[1] Singapore Gen Hosp, Dept Orthopaed Surg, Outram Rd Acad Bldg Level 4, Singapore 119228, Singapore

[2] Endocrine Clin, Mt Elizabeth Med Ctr, 3 Mt Elizabeth 15-04, Singapore 228510, Singapore

[3] Singapore Gen Hosp, Dept Diagnost Radiol, Block 2,Level 1,Outram Rd, Singapore 169608, Singapore

来源：

CALCIFIED TISSUE INTERNATIONAL | 2022年 / 111卷 / 01期

关键词：

Osteoporosis; Atypical femur fractures; Stress fractures; Prolia; Denosumab; Bisphosphonates; BONE TURNOVER MARKERS; POSTMENOPAUSAL WOMEN; FEMORAL FRACTURES; RECEIVING DENOSUMAB; OSTEOPOROSIS; TERIPARATIDE; MANAGEMENT;

D O I：

10.1007/s00223-022-00952-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A case report of bilateral atypical femur fractures (AFF) in a bisphosphonate naive patient. A 62-year-old female bisphosphonate naive patient was started on denosumab for osteoporosis. Approximately 3 years later she complained of right hip pain and was found to have a bilateral incomplete AFFs. She was asymptomatic on the left lower limb. Patient was managed conservatively and placed on protected weight bearing on both legs. Symptoms subsequently resolved over a period of 3 months, although radiographic findings remained at approximately 1 year. AFFs may be associated with patients on denosumab therapy even without a prior history of bisphosphonate use. Patients should be counselled appropriately and monitored for such complications.

引用

页码：96 / 101

页数：6

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