Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles

被引：117

作者：

Wood, ER ^{[1
]}

Kuyper, L ^{[1
]}

Petrov, KG ^{[1
]}

Hunter, RN ^{[1
]}

Harris, PA ^{[1
]}

Lackey, K ^{[1
]}

机构：

[1] GlaxoSmithKline, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 04期

关键词：

TrkA kinase inhibitors;

D O I：

10.1016/j.bmcl.2003.12.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-hydroxy-5-(2'-methoxyphenyl)-benzylidene)-5-bromo-1,3-dihydro-pyrrolo[2,3-b]-pyridin-2-one, 3-[(1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one as potent TrkA inhibitors are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：953 / 957

页数：5

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