Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes

被引:18
作者
Ferreira-Hermosillo, Aldo [1 ]
Molina-Ayala, Mario [1 ]
Ramirez-Renteria, Claudia [2 ]
Vargas, Guadalupe [1 ]
Gonzalez, Baldomero [1 ]
Isibasi, Armando [3 ]
Archundia-Riveros, Irma [3 ]
Mendoza, Victoria [1 ]
机构
[1] IMSS, Endocrinol Dept, Hosp Especialidades Ctr Med Nacl Siglo 21, Mexico City 06720, Mex, Mexico
[2] IMSS, Expt Endocrinol Invest Unit, Hosp Especialidades Ctr Med Nacl Siglo 21, Mexico City 06720, Mex, Mexico
[3] IMSS, Immunochem Med Invest Unit, Hosp Especialidades Ctr Med Nacl Siglo 21, Mexico City 06720, Mex, Mexico
关键词
GLUCOSE DISPOSAL RATE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; MEXICAN ADULTS; OBESITY; RISK; COMPLICATIONS; MARKERS; PREVALENCE; MORTALITY;
D O I
10.1155/2015/972073
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To compare the serum concentration of IL-6, IL-10, TNF, IL-8, resistin, and adiponectin in type 1 diabetic patients with and without metabolic syndrome and to determine the cut-off point of the estimated glucose disposal rate that accurately differentiated these groups. Design. We conducted a cross-sectional evaluation of all patients in our type 1 diabetes clinic from January 2012 to January 2013. Patients were considered to have metabolic syndrome when they fulfilled the joint statement criteria and were evaluated for clinical, biochemical, and immunological features. Methods. We determined serum IL-6, IL-8, IL-10, and TNF with flow cytometry and adiponectin and resistin concentrations with enzyme linked immunosorbent assay in patients with and without metabolic syndrome. We also compared estimated glucose disposal rate between groups. Results. We tested 140 patients. Forty-four percent fulfilled the metabolic syndrome criteria (n = 61), 54% had central obesity, 30% had hypertriglyceridemia, 29% had hypoalphalipoproteinemia, and 19% had hypertension. We observed that resistin concentrations were higher in patients with MS. Conclusion. We found a high prevalence of MS in Mexican patients with T1D. The increased level of resistin may be related to the increased fat mass and could be involved in the development of insulin resistance.
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页数:7
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