The immune system as a self-centered network of lymphocytes

被引：9
作者：
Santori, Fabio R. [1 ]
机构：
[1] NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
来源：
IMMUNOLOGY LETTERS | 2015年 / 166卷 / 02期
关键词：
Immunology; Self-peptides; Immune networks; T cells; B cells; Autoimmunity; REGULATORY T-CELLS; LY-1; B-CELLS; POSITIVE SELECTION; ANTIGEN-FREE; MEVALONATE PATHWAY; AUTOIMMUNE-DISEASE; ACCESSORY CELLS; REPERTOIRE; PEPTIDE; EXPRESSION;
D O I：
10.1016/j.imlet.2015.06.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This essay makes a brief historical and comparative review of selective and network theories of the immune system which is presented as a chemical sensory system with immune and non-immune functions. The ontogeny of immune networks is the result of both positive and negative selection of lymphocytes to self-epitopes that serve as a "template" for the recognition of foreign antigens. The development of immune networks progresses from single individual clones in early ontogeny into complex "information processing networks" in which lymphocytes are linked to inhibitory and stimulatory immune cells. The results of these regulatory interactions modulate immune responses and tolerance. (C) 2015 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：109 / 116
页数：8
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