Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis

被引:13
作者
Chikhoune, Liticia [1 ]
Brousseau, Thierry [2 ]
Morell-Dubois, Sandrine [1 ]
Farhat, Meryem Maud [1 ,3 ,4 ]
Maillard, Helene [1 ]
Ledoult, Emmanuel [1 ,3 ,4 ]
Lambert, Marc [1 ]
Yelnik, Cecile [1 ]
Sanges, Sebastien [1 ,3 ,4 ]
Sobanski, Vincent [1 ,3 ,4 ]
Hachulla, Eric [1 ,3 ,4 ]
Launay, David [1 ,3 ,4 ]
机构
[1] CHU Lille, Serv Med Interne & Immunol Clin, Ctr Reference Malad Autoimmunes Syst Rares Nord &, F-59000 Lille, France
[2] CHU Lille, Serv Biochim Automatisee Prot, F-59000 Lille, France
[3] Univ Lille, INFINITE Inst Translat Res Inflammat U1286, F-59000 Lille, France
[4] INSERM, F-59000 Lille, France
关键词
systemic sclerosis; biomarkers; interstitial lung disease; prognosis; INTERSTITIAL LUNG-DISEASE; C-REACTIVE PROTEIN; MORTALITY; CRITERIA; PREDICT;
D O I
10.3390/jcm11175087
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
(1) Background: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with a high mortality and morbidity rate. Identification of biomarkers that can predict the evolution of SSc is a key factor in the management of patients. The aim of this study was to assess the association of routine laboratory parameters, widely used in practice and easily available, with the severity and progression of SSc. (2) Methods: In this retrospective monocentric cohort study, 372 SSc patients were included. We gathered clinical and laboratory data including routine laboratory parameters: C-reactive-protein (CRP), erythrocyte sedimentation rate (ESR), complete blood count, serum sodium and potassium levels, creatinin, urea, ferritin, albumin, uric acid, N-terminal pro-brain natriuretic peptide (NTproBNP), serum protein electrophoresis, and liver enzymes. Associations between these routine laboratory parameters and clinical presentation and outcome were assessed. (3) Results: Median (interquartile range) age was 59.0 (50.0; 68.0) years. White blood cell, monocyte, and neutrophil absolute counts were significantly higher in patients with diffuse cutaneous SSc and with interstitial lung disease (ILD) (p < 0.001). CRP was significantly higher in patients with ILD (p < 0.001). Hemoglobin and ferritin were significantly lower in patients with pulmonary hypertension (PH) including pulmonary arterial hypertension and ILD associated PH (p = 0.016 and 0.046, respectively). Uric acid and NT pro BNP were significantly higher in patients with PH (<0.001). Monocyte count was associated with ILD progression over time. (4) Conclusions: Overall, our study highlights the association of routine laboratory parameters used in current practice with the severity and progression of SSc.
引用
收藏
页数:14
相关论文
共 40 条
[11]   Iron deficiency in pulmonary arterial hypertension: prevalence and potential usefulness of oral supplementation [J].
Ghio, Stefano ;
Fortuni, Federico ;
Capettini, Anna Clizia ;
Scelsi, Laura ;
Greco, Alessandra ;
Vullo, Eleonora ;
Raineri, Claudia ;
Guida, Stefania ;
Turco, Annalisa ;
Gargiulo, Chiara ;
Visconti, Luigi Oltrona .
ACTA CARDIOLOGICA, 2021, 76 (02) :162-167
[12]   Biomarkers in systemic sclerosis: Their potential to predict clinical courses [J].
Hasegawa, Minoru .
JOURNAL OF DERMATOLOGY, 2016, 43 (01) :29-38
[13]   Circulating Protein Biomarkers in Systemic Sclerosis Related Pulmonary Arterial Hypertension: A Review of Published Data [J].
Hickey, Peter M. ;
Lawrie, Allan ;
Condliffe, Robin .
FRONTIERS IN MEDICINE, 2018, 5
[14]   Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database [J].
Hoffmann-Vold, Anna-Maria ;
Allanore, Yannick ;
Alves, Margarida ;
Brunborg, Cathrine ;
Airo, Paolo ;
Ananieva, Lidia P. ;
Czirjak, Laszlo ;
Guiducci, Serena ;
Hachulla, Eric ;
Li, Mengtao ;
Mihai, Carina ;
Riemekasten, Gabriela ;
Sfikakis, Petros P. ;
Kowal-Bielecka, Otylia ;
Riccardi, Antonella ;
Distler, Oliver .
ANNALS OF THE RHEUMATIC DISEASES, 2021, 80 (02) :219-227
[15]   Risk Factors for Mortality and Cardiopulmonary Hospitalization in Systemic Sclerosis Patients At Risk for Pulmonary Hypertension, in the PHAROS Registry [J].
Hsu, Vivien M. ;
Chung, Lorinda ;
Hummers, Laura K. ;
Shah, Ami ;
Simms, Robert ;
Bolster, Marcy ;
Hant, Faye N. ;
Silver, Richard M. ;
Fischer, Aryeh ;
Hinchcliff, Monique E. ;
Varga, John ;
Goldberg, Avram Z. ;
Derk, Chris T. ;
Schiopu, Elena ;
Khanna, Dinesh ;
Shapiro, Lee S. ;
Domsic, Robyn T. ;
Medsger, Thomas ;
Mayes, Maureen D. ;
Furst, Daniel ;
Csuka, Mary Ellen ;
Molitor, Jerry A. ;
Saketkoo, Lesley Ann ;
Salazar, Christian R. ;
Steen, Virginia D. .
JOURNAL OF RHEUMATOLOGY, 2019, 46 (02) :176-183
[16]   Biomarkers of skin and lung fibrosis in systemic sclerosis [J].
Kaliterna, Dusanka Martinovic ;
Petric, Marin .
EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2019, 15 (11) :1215-1223
[17]   Increased monocyte count and red cell distribution width as prognostic biomarkers in patients with Idiopathic Pulmonary Fibrosis [J].
Karampitsakos, Theodoros ;
Torrisi, Sebastiano ;
Antoniou, Katerina ;
Manali, Effrosyni ;
Korbila, Ioanna ;
Papaioannou, Ourania ;
Sampsonas, Fotios ;
Katsaras, Matthaios ;
Vasarmidi, Eirini ;
Papakosta, Despoina ;
Domvri, Kalliopi ;
Fouka, Eva ;
Organtzis, Ioannis ;
Daniil, Zoe ;
Dimeas, Ilias ;
Kirgou, Paraskevi ;
Gourgoulianis, Konstantinos I. ;
Papanikolaou, Ilias C. ;
Markopoulou, Katerina ;
Kounti, Georgia ;
Tsapakidou, Eirini ;
Papadopoulou, Efthymia ;
Tatsis, Konstantinos ;
Gogali, Athena ;
Kostikas, Konstantinos ;
Tzilas, Vasilios ;
Chrysikos, Serafeim ;
Papiris, Spyridon ;
Bouros, Demosthenes ;
Kreuter, Michael ;
Tzouvelekis, Argyrios .
RESPIRATORY RESEARCH, 2021, 22 (01)
[18]   Etiology, Risk Factors, and Biomarkers in Systemic Sclerosis with Interstitial Lung Disease [J].
Khanna, Dinesh ;
Tashkin, Donald P. ;
Denton, Christopher P. ;
Renzoni, Elisabetta A. ;
Desai, Sujal R. ;
Varga, John .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201 (06) :650-660
[19]   Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis [J].
Ledoult, Emmanuel ;
Launay, David ;
Behal, Helene ;
Mouthon, Luc ;
Pugnet, Gregory ;
Lega, Jean-Christophe ;
Agard, Christian ;
Allanore, Yannick ;
Jego, Patrick ;
Fauchais, Anne-Laure ;
Harle, Jean-Robert ;
Berthier, Sabine ;
Aouba, Achille ;
Mekinian, Arsene ;
Diot, Elisabeth ;
Truchetet, Marie-Elise ;
Boulon, Carine ;
Duhamel, Alain ;
Hachulla, Eric ;
Sobanski, Vincent .
ARTHRITIS RESEARCH & THERAPY, 2020, 22 (01)
[20]   CD16-positive circulating monocytes and fibrotic manifestations of systemic sclerosis [J].
Lescoat, Alain ;
Lecureur, Valerie ;
Roussel, Mikael ;
Sunnaram, Beatrice Ly ;
Ballerie, Alice ;
Coiffier, Guillaume ;
Jouneau, Stephane ;
Fardel, Olivier ;
Fest, Thierry ;
Jego, Patrick .
CLINICAL RHEUMATOLOGY, 2017, 36 (07) :1649-1654