Association between Routine Laboratory Parameters and the Severity and Progression of Systemic Sclerosis

被引:13
作者
Chikhoune, Liticia [1 ]
Brousseau, Thierry [2 ]
Morell-Dubois, Sandrine [1 ]
Farhat, Meryem Maud [1 ,3 ,4 ]
Maillard, Helene [1 ]
Ledoult, Emmanuel [1 ,3 ,4 ]
Lambert, Marc [1 ]
Yelnik, Cecile [1 ]
Sanges, Sebastien [1 ,3 ,4 ]
Sobanski, Vincent [1 ,3 ,4 ]
Hachulla, Eric [1 ,3 ,4 ]
Launay, David [1 ,3 ,4 ]
机构
[1] CHU Lille, Serv Med Interne & Immunol Clin, Ctr Reference Malad Autoimmunes Syst Rares Nord &, F-59000 Lille, France
[2] CHU Lille, Serv Biochim Automatisee Prot, F-59000 Lille, France
[3] Univ Lille, INFINITE Inst Translat Res Inflammat U1286, F-59000 Lille, France
[4] INSERM, F-59000 Lille, France
关键词
systemic sclerosis; biomarkers; interstitial lung disease; prognosis; INTERSTITIAL LUNG-DISEASE; C-REACTIVE PROTEIN; MORTALITY; CRITERIA; PREDICT;
D O I
10.3390/jcm11175087
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
(1) Background: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with a high mortality and morbidity rate. Identification of biomarkers that can predict the evolution of SSc is a key factor in the management of patients. The aim of this study was to assess the association of routine laboratory parameters, widely used in practice and easily available, with the severity and progression of SSc. (2) Methods: In this retrospective monocentric cohort study, 372 SSc patients were included. We gathered clinical and laboratory data including routine laboratory parameters: C-reactive-protein (CRP), erythrocyte sedimentation rate (ESR), complete blood count, serum sodium and potassium levels, creatinin, urea, ferritin, albumin, uric acid, N-terminal pro-brain natriuretic peptide (NTproBNP), serum protein electrophoresis, and liver enzymes. Associations between these routine laboratory parameters and clinical presentation and outcome were assessed. (3) Results: Median (interquartile range) age was 59.0 (50.0; 68.0) years. White blood cell, monocyte, and neutrophil absolute counts were significantly higher in patients with diffuse cutaneous SSc and with interstitial lung disease (ILD) (p < 0.001). CRP was significantly higher in patients with ILD (p < 0.001). Hemoglobin and ferritin were significantly lower in patients with pulmonary hypertension (PH) including pulmonary arterial hypertension and ILD associated PH (p = 0.016 and 0.046, respectively). Uric acid and NT pro BNP were significantly higher in patients with PH (<0.001). Monocyte count was associated with ILD progression over time. (4) Conclusions: Overall, our study highlights the association of routine laboratory parameters used in current practice with the severity and progression of SSc.
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页数:14
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