The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia

被引：92

作者：

Groeschel, Matthias I. ^{[1
,2
]}

Meehan, Conor J. ^{[3
]}

Barilar, Ivan ^{[1
]}

Diricks, Margo ^{[4
]}

Gonzaga, Aitor ^{[5
]}

Steglich, Matthias ^{[5
]}

Conchillo-Sole, Oscar ^{[6
,7
]}

Scherer, Isabell-Christin ^{[8
]}

Mamat, Uwe ^{[9
]}

Luz, Christian F. ^{[10
]}

De Bruyne, Katrien ^{[4
]}

Utpatel, Christian ^{[1
]}

Yero, Daniel ^{[6
,7
]}

Gibert, Isidre ^{[6
,7
]}

Daura, Xavier ^{[6
,11
]}

Kampmeier, Stefanie ^{[12
]}

Rahman, Nurdyana Abdul ^{[13
]}

Kresken, Michael ^{[14
,15
]}

van der Werf, Tjip S. ^{[2
]}

Alio, Ifey ^{[16
]}

Streit, Wolfgang R. ^{[16
]}

Zhou, Kai ^{[17
,18
]}

Schwartz, Thomas ^{[19
]}

Rossen, John W. A. ^{[10
]}

Farhat, Maha R. ^{[20
,21
]}

Schaible, Ulrich E. ^{[9
,22
,23
]}

Nuebel, Ulrich ^{[5
,23
,24
,25
]}

Rupp, Jan ^{[8
,22
]}

Steinmann, Joerg ^{[26
,27
]}

Niemann, Stefan ^{[1
,22
,23
]}

Kohl, Thomas A. ^{[1
,22
]}

机构：

[1] Res Ctr Borstel, Mol & Expt Mycobacteriol, Borstel, Germany

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis & TB, Groningen, Netherlands

[3] Univ Bradford, Sch Chem & Biosci, Bradford, W Yorkshire, England

[4] Appl Maths NV, BioMerieux, Keistr 120, B-9830 St Martens Latem, Belgium

[5] German Collect Microorganisms & Cell Cultures, Leibniz Inst DSMZ, Braunschweig, Germany

[6] Univ Autonoma Barcelona, Inst Biotechnol & Biomed, Barcelona, Spain

[7] Univ Autonoma Barcelona, Dept Genet & Microbiol, Barcelona, Spain

[8] Univ Hosp Schleswig Holstein, Dept Infect Dis & Microbiol, Lubeck, Germany

[9] Res Ctr Borstel, Cellular Microbiol, Borstel, Germany

[10] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol & Infect Prevent, Groningen, Netherlands

[11] Catalan Inst Res & Adv Studies, Barcelona, Spain

[12] Univ Hosp Munster, Inst Hyg, Munster, Germany

[13] Singapore Gen Hosp, Dept Microbiol, Singapore, Singapore

[14] Antiinfect Intelligence GmbH, Rheinbach, Germany

[15] Koln gGmbH, Rhein Fachhsch, Cologne, Germany

[16] Univ Hamburg, Dept Microbiol & Biotechnol, Hamburg, Germany

[17] Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen Inst Resp Dis, Shenzhen, Peoples R China

[18] Jinan Univ, Clin Med Coll 2, Shenzhen, Peoples R China

[19] Karlsruhe Inst Technol, Inst Funct Interfaces, Eggenstein Leopoldshafen, Germany

[20] Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA

[21] Massachusetts Gen Hosp, Div Pulm & Crit Care, Boston, MA 02114 USA

[22] German Ctr Infect Res DZIF, Partner Site Hamburg Lubeck Borstel Riems, Cologne, Germany

[23] Leibniz Res Alliance INFECTI 21, Cologne, Germany

[24] Germany Ctr Infect Res DZIF, Partner Site Hannover Braunschweig, Cologne, Germany

[25] Tech Univ, Braunschweig Integrated Ctr Syst Biol BRICS, Braunschweig, Germany

[26] Univ Med Ctr Essen, Inst Med Microbiol, Essen, Germany

[27] Paracelsus Med Private Univ, Klinikum Nurnberg, Inst Clin Hyg, Med Microbiol & Infect Prevent, Nurnberg, Germany

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

基金：

欧盟地平线“2020”; 中国国家自然科学基金;

关键词：

SEQUENCE TYPING SCHEME; INFECTIONS; ANNOTATION; DISEASE; PROTEIN; TREE; TOOL;

D O I：

10.1038/s41467-020-15123-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals. Multidrug resistance of the opportunistic pathogen Stenotrophomonas maltophilia is an increasing problem. Here, analyzing strains from 22 countries, the authors show that the S. maltophilia complex is divided into 23 monophyletic lineages and find evidence for intra-hospital transmission.

引用

页数：12

共 73 条

[1]

[Anonymous], NAT MICROBIOL, DOI DOI 10.1038/NMICROBIOL

[2]

[Anonymous], JMM CASE REP

[3]

[Anonymous], PUBL HLTH IMP ANT RE

[4]

[Anonymous], J OPEN SOURCE SOFTW

[5] Gene Ontology: tool for the unification of biology [J].

Ashburner, M ;

Ball, CA ;

Blake, JA ;

Botstein, D ;

Butler, H ;

Cherry, JM ;

Davis, AP ;

Dolinski, K ;

Dwight, SS ;

Eppig, JT ;

Harris, MA ;

Hill, DP ;

Issel-Tarver, L ;

Kasarskis, A ;

Lewis, S ;

Matese, JC ;

Richardson, JE ;

Ringwald, M ;

Rubin, GM ;

Sherlock, G .

NATURE GENETICS, 2000, 25 (01) :25-29

[6] Inexpensive Multiplexed Library Preparation for Megabase-Sized Genomes [J].

Baym, Michael ;

Kryazhimskiy, Sergey ;

Lieberman, Tami D. ;

Chung, Hattie ;

Desai, Michael M. ;

Kishony, Roy .

PLOS ONE, 2015, 10 (05)

[7] Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants [J].

Blanco, Paula ;

Hernando-Amado, Sara ;

Antonio Reales-Calderon, Jose ;

Corona, Fernando ;

Lira, Felipe ;

Alcalde-Rico, Manuel ;

Bernardini, Alejandra ;

Blanca Sanchez, Maria ;

Luis Martinez, Jose .

MICROORGANISMS, 2016, 4 (01)

[8] New strategies against Stenotrophomonas maltophilia: a serious worldwide intrinsically drug-resistant opportunistic pathogen [J].

Brooke, Joanna S. .

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2014, 12 (01) :1-4

[9] Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen [J].

Brooke, Joanna S. .

CLINICAL MICROBIOLOGY REVIEWS, 2012, 25 (01) :2-41

[10] Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium [J].

Bryant, Josephine M. ;

Grogono, Dorothy M. ;

Rodriguez-Rincon, Daniela ;

Everall, Isobel ;

Brown, Karen P. ;

Moreno, Pablo ;

Verma, Deepshikha ;

Hill, Emily ;

Drijkoningen, Judith ;

Gilligan, Peter ;

Esther, Charles R. ;

Noone, Peadar G. ;

Giddings, Olivia ;

Bell, Scott C. ;

Thomson, Rachel ;

Wainwright, Claire E. ;

Coulter, Chris ;

Pandey, Sushil ;

Wood, Michelle E. ;

Stockwell, Rebecca E. ;

Ramsay, Kay A. ;

Sherrard, Laura J. ;

Kidd, Timothy J. ;

Jabbour, Nassib ;

Johnson, Graham R. ;

Knibbs, Luke D. ;

Morawska, Lidia ;

Sly, Peter D. ;

Jones, Andrew ;

Bilton, Diana ;

Laurenson, Ian ;

Ruddy, Michael ;

Bourke, Stephen ;

Bowler, Ian C. J. W. ;

Chapman, Stephen J. ;

Clayton, Andrew ;

Cullen, Mairi ;

Dempsey, Owen ;

Denton, Miles ;

Desai, Maya ;

Drew, Richard J. ;

Edenborough, Frank ;

Evans, Jason ;

Folb, Jonathan ;

Daniels, Thomas ;

Humphrey, Helen ;

Isalska, Barbara ;

Jensen-Fangel, Soren ;

Jonsson, Bodil ;

Jones, Andrew M. .

SCIENCE, 2016, 354 (6313) :751-757

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