Improvement of erectile function with Prelox: a randomized, double-blind, placebo-controlled, crossover trial

被引：26

作者：

Stanislavov, R. ^{[2
]}

Nikolova, V. ^{[2
]}

Rohdewald, P. ^{[1
]}

机构：

[1] Univ Munster, Inst Pharmaceut Chem, Munster, Germany

[2] Med Univ Sofia, Fac Med, Dept Obstet & Gynecol, Sofia, Bulgaria

来源：

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH | 2008年 / 20卷 / 02期

关键词：

erectile dysfunction; Prelox; L-arginine; Pycnogenol; endothelial nitric oxide synthase (e-NOS);

D O I：

10.1038/sj.ijir.3901597

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In a randomly allocated, double-blind, placebo-controlled, crossover design, 50 patients with mild to moderate erectile dysfunction (ED) were treated for 1 month with placebo or a combination of L-arginine aspartate and Pycnogenol (Prelox). Patients reported sexual function from diaries. Testosterone levels and endothelial NO synthase (e-NOS) were monitored along with routine clinical chemistry. Intake of Pycnogenol for 1 month restored erectile function to normal. Intercourse frequency doubled. e-NOS in spermatozoa and testosterone levels in blood increased significantly. Cholesterol levels and blood pressure were lowered. No unwanted effects were reported. Prelox is a promising alternative to treat mild to moderate ED.

引用

页码：173 / 180

页数：8

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