Improvement of erectile function with Prelox: a randomized, double-blind, placebo-controlled, crossover trial

被引：26
作者：
Stanislavov, R. [2 ]
Nikolova, V. [2 ]
Rohdewald, P. [1 ]
机构：
[1] Univ Munster, Inst Pharmaceut Chem, Munster, Germany
[2] Med Univ Sofia, Fac Med, Dept Obstet & Gynecol, Sofia, Bulgaria
来源：
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH | 2008年 / 20卷 / 02期
关键词：
erectile dysfunction; Prelox; L-arginine; Pycnogenol; endothelial nitric oxide synthase (e-NOS);
D O I：
10.1038/sj.ijir.3901597
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In a randomly allocated, double-blind, placebo-controlled, crossover design, 50 patients with mild to moderate erectile dysfunction (ED) were treated for 1 month with placebo or a combination of L-arginine aspartate and Pycnogenol (Prelox). Patients reported sexual function from diaries. Testosterone levels and endothelial NO synthase (e-NOS) were monitored along with routine clinical chemistry. Intake of Pycnogenol for 1 month restored erectile function to normal. Intercourse frequency doubled. e-NOS in spermatozoa and testosterone levels in blood increased significantly. Cholesterol levels and blood pressure were lowered. No unwanted effects were reported. Prelox is a promising alternative to treat mild to moderate ED.
引用
收藏
页码：173 / 180
页数：8
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