Protective effect of curcumin against rotenone-induced substantia nigra pars compacta neuronal dysfunction

被引：6
作者：
Darbinyan, L., V [1 ]
Simonyan, K., V [2 ]
Hambardzumyan, L. E. [1 ]
Manukyan, L. P. [1 ]
Badalyan, S. H. [1 ]
Sarkisian, V. H. [1 ]
机构：
[1] Orbeli Inst Physiol NAS RA, Sensorimotor Integrat Lab, Yerevan 0028, Armenia
[2] Orbeli Inst Physiol NAS RA, Neuroendocrine Relationships Lab, Yerevan 0028, Armenia
来源：
METABOLIC BRAIN DISEASE | 2022年 / 37卷 / 04期
关键词：
Curcumin; Rotenone; Substantia nigra pars compacta; In vivo electrophysiology; PARKINSONS-DISEASE; DOPAMINE NEURONS; RAT MODEL; INHIBITION; DEGENERATION; SYNAPSES; NUCLEUS; AGENT;
D O I：
10.1007/s11011-022-00941-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rotenone is involved in the degeneration of dopaminergic neurons, and curcumin may prevent or effectively slow the progression of Parkinson's disease (PD). Previous research has shown that the naturally occurring phenolic compound curcumin can reduce inflammation and oxidation, making it a potential therapeutic agent for neurodegenerative diseases. The present study involves investigation of rotenone-induced histological changes in the brain area, hippocampus using Nissl staining after 35 day of subcutaneous injection of rotenone in adult male rats. We sought to determine whether curcumin could protect against rotenone-induced dopaminergic neurotoxicity in a rat model by in vivo electrical recording from Substantia nigra pars compacta (SNc). Curcumin treatment significantly improved electrical activity of neurons in the SNc of rotenone-induced PD model rats. The pattern of histological alterations corresponds with electrophysiological manifestations.
引用
收藏
页码：1111 / 1118
页数：8
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