Enantioselective addition of dialkylzinc to aldehydes catalyzed by (S)-2-(N,N-disubstituted aminomethyl)indoline

被引：55
作者：
Asami, M [1 ]
Watanabe, H [1 ]
Honda, K [1 ]
Inoue, S [1 ]
机构：
[1] Yokohama Natl Univ, Fac Engn, Dept Synthet Chem, Hodogaya Ku, Yokohama, Kanagawa 2408501, Japan
来源：
TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 23期
关键词：
D O I：
10.1016/S0957-4166(98)00446-7
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Chiral di- or triamines, (S)-2-(N,N-disubstituted aminomethyl)indoline 1a-d, derived from (S)-indoline-2-carboxylic acid were efficient chiral catalysts for the enantioselective addition of dialkylzincs to aldehydes. The best results were obtained by employing 15 mol% of (S)-2-(4-methylpiperazin-1-ylmethyl)indoline Ic, and chiral secondary alcohols were obtained in up to 97% ee. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：4165 / 4173
页数：9
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