Protective effect of P-fraternus against ethanol-induced mitochondrial dysfunction

被引：16

作者：

Sebastian, T ^{[1
]}

Setty, OH ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Life Sci, Dept Biochem, Hyderabad 500046, Andhra Pradesh, India

来源：

ALCOHOL | 1999年 / 17卷 / 01期

关键词：

chronic ethanol consumption; oxidative phosphorylation; mitochondrial dysfunction; Phyllanthus fraternus; electron transport chain; P/O ratio; respiratory control ratio;

D O I：

10.1016/S0741-8329(98)00029-9

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Chronic ethanol consumption (10 g per kg body weight) significantly decreased the rate of respiration, P/O ratio, and respiratory control ratio (RCR). The activities of NADH dehydrogenase and cytochrome oxidase were significantly decreased in submitochondrial particles by ethanol administration compared to control. No significant difference was observed in membrane potential of submitochondrial particles. Cytochrome b, c and aa(3) content of mitochondria were significantly decreased by ethanol feeding. Ethanol-induced inhibition on rate of respiration, P/O ratio, and RCR was relieved to a great extent by the administration of the aqueous extract of Phyllanthus fraternus (100 mg dry powder of the plant per kg body weight) along with ethanol. The decrease in the content of cytochromes due to ethanol administration was revived partially by aqueous extract of P. fraternus. (C) 1998 Elsevier Science Inc.

引用

页码：29 / 34

页数：6

共 33 条

[1] CRYSTALLINE CONSTITUENTS OF EUPHORBIACEAE .12. ISOLATION AND STRUCTURAL ELUCIDATION OF 3 NEW LIGNANS FROM LEAVES OF PHYLLANTHUS-NIRURI LINN [J].

ANJANEYULU, AS ;

RAO, KJ ;

SUBRAHMANYAM, C ;

ROW, LR .

TETRAHEDRON, 1973, 29 (10) :1291-1298

[2] DECREASED CYTOCHROME-OXIDASE ACTIVITY IN HEPATIC MITOCHONDRIA AFTER CHRONIC ETHANOL-CONSUMPTION AND THE POSSIBLE ROLE OF DECREASED CYTOCHROME-AA3 CONTENT AND CHANGES IN PHOSPHOLIPIDS [J].

ARAI, M ;

GORDON, ER ;

LIEBER, CS .

BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 797 (03) :320-327

[3]

AZZI A, 1971, J BIOL CHEM, V246, P2035

[4] EFFECTS OF CHRONIC ETHANOL TREATMENT UPON RAT-LIVER MITOCHONDRIA [J].

BERNSTEIN, JD ;

PENNIALL, R .

BIOCHEMICAL PHARMACOLOGY, 1978, 27 (19) :2337-2342

[5]

Chopra RN., 1956, Glossary of indian medicinal plants, P191

[6] EFFECTS OF CHRONIC ETHANOL-CONSUMPTION ON THE SYNTHESIS OF POLYPEPTIDES ENCODED BY THE HEPATIC MITOCHONDRIAL GENOME [J].

COLEMAN, WB ;

CUNNINGHAM, CC .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1019 (02) :142-150

[7]

COOPERSTEIN SJ, 1951, J BIOL CHEM, V189, P665

[8]

Dixit S. P., 1983, J NATL INTEG MED ASS, V25, P269

[9]

DWIVEDI Y, 1990, INDIAN J MED RES-B, V92, P195

[10]

Estabrook R.W., 1967, METHODS ENZYMOL, V10, P41, DOI DOI 10.1016/0076-6879(67)10010-4

← 1 2 3 4 →