Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents

被引：113

作者：

Zhang, Yi-Yi ^{[1
]}

Zhou, Cheng-He ^{[1
]}

机构：

[1] Southwest Univ, Sch Chem & Chem Engn, Lab Bioorgan & Med Chem, Chongqing 400715, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 14期

关键词：

Naphthalimide; 1,2,4-Triazole; Imidazole; Antibacterial; Antifungal; BIOLOGICAL EVALUATION; CYCLIC IMIDES; ANTICANCER; DERIVATIVES; FLUORINE; DESIGN;

D O I：

10.1016/j.bmcl.2011.05.042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Naphthalimide-derived azoles as a new type of antimicrobial agents were synthesized and evaluated for their efficiency in vitro against eight bacteria and two fungi by two fold serial dilution technique. Most title compounds exhibited good antimicrobial potency with low MIC values ranging from 1 to 16 mu g/mL. Notably, some synthesized compounds displayed comparable or even better antibacterial and antifungal activities against some tested strains than the reference drugs Orbifloxacin, Chloromycin and Fluconazole, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：4349 / 4352

页数：4

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