Albumin binding ligands and albumin conjugate uptake by cancer cells

被引：83

作者：

Frei, Eva ^{[1
,2
]}

机构：

[1] German Canc Res Ctr, Div Prevent Oncol, D-69120 Heidelberg, Germany

[2] Natl Ctr Tumor Dis, D-69120 Heidelberg, Germany

来源：

DIABETOLOGY & METABOLIC SYNDROME | 2011年 / 3卷

关键词：

Insulin detemir; aminofluorescein-albumin; methotrexate-albumin; clathrin-heavy-chain; lysosomes; fatty acids; HUMAN SERUM-ALBUMIN; METHOTREXATE-ALBUMIN; DRUG-DELIVERY; PROTEINS; TRIAL;

D O I：

10.1186/1758-5996-3-11

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The scope of this short review is to summarise the knowledge gleaned from the fate of drugs transported by albumin upon contact with the target cancer cell or cells in inflamed tissues. The authors expertise covers covalently bound drugs and their cellular uptake and release from albumin. This review therefore aims to deduce what will happen to drugs such as insulin detemir which is considered to bind non-covalently to albumin and may have a fate similar to fatty acids transported by albumin.

引用

页数：4

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