Runs of Homozygosity Do Not Influence Survival to Old Age

被引：9
作者：
Kuningas, Maris [1 ]
McQuillan, Ruth [2 ]
Wilson, James F. [2 ]
Hofman, Albert [1 ,3 ]
van Duijn, Cornelia M. [1 ,3 ]
Uitterlinden, Andre G. [1 ,3 ,4 ]
Tiemeier, Henning [1 ,3 ,5 ]
机构：
[1] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands
[2] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland
[3] Netherlands Consortium Healthy Aging, Netherlands Genom Initiat, Leiden, Netherlands
[4] Erasmus Univ, Med Ctr, Dept Internal Med, Rotterdam, Netherlands
[5] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands
来源：
PLOS ONE | 2011年 / 6卷 / 07期
关键词：
EXTENDED TRACTS; POPULATIONS; IDENTIFY;
D O I：
10.1371/journal.pone.0022580
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH larger than 1.5 Mb individually and in combination for association with survival in 5974 participants of the Rotterdam Study. In addition, we assessed the role of overall homozygosity, expressed as a percentage of the autosomal genome that is in ROH longer than 1.5 Mb, on survival during a mean follow-up period of 12 years. None of these measures of homozygosity was associated with survival to old age.
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页数：3
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