Detection by radioligand assay of antibodies against Borna disease virus in patients with various psychiatric disorders

被引：15

作者：

Matsunaga, H

Tanaka, S

Sasao, F

Nishino, Y

Takeda, M

Tomonaga, K

Ikuta, K

Amino, N

机构：

[1] Osaka Gen Med Ctr, Dept Psychiat, Sumiyoshi Ku, Osaka 5588558, Japan

[2] Tokyo Metropolitan Org Med Res, Tokyo Inst Psychiat, Dept Sleep Disorders Res, Tokyo 1568585, Japan

[3] Osaka Univ, Res Inst Microbial Dis, Dept Virol, Suita, Osaka 5650871, Japan

[4] Azabu Univ, Biosci Res Inst, Kanagawa 2298501, Japan

[5] Osaka Univ, Grad Sch Med, Dept Psychiat, Suita, Osaka 5650871, Japan

[6] Kuma Hosp, Kobe, Hyogo 6500011, Japan

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2005年 / 12卷 / 05期

关键词：

D O I：

10.1128/CDLI.12.5.671-676.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using a radioligand assay, which preserves the natural form of the antigen, antibodies against Borna disease virus nucleoprotein and phosphoprotein were detected in 11 and 19 sera of 171 psychiatric patients, respectively. Compared with results by Western blotting, three and nine sera were concordantly positive, respectively. The four sera showing the highest levels of antibodies by radioligand assay were all negative by Western blotting; however, dilution and inhibition tests supported the positive results. Our results suggest the importance of conformational structure to detect human anti-Borna disease virus antibodies.

引用

页码：671 / 676

页数：6

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