Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies

被引：288
作者：
Jurcau, Anamaria [1 ,2 ]
Simion, Aurel [1 ,3 ]
机构：
[1] Univ Oradea, Fac Med & Pharm, Dept Psychoneurosci & Rehabil, Oradea 410087, Romania
[2] Clin Municipal Hosp Dr G Curteanu Oradea, Neurol Ward, Oradea 410154, Romania
[3] Clin Municipal Hosp Dr G Curteanu Oradea, Neurorehabil Ward, Oradea 410154, Romania
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 01期
关键词：
ischemic stroke; neuroinflammation; microglia; astrocytes; chemokines; cytokines; stem cells; REGULATORY T-CELLS; CENTRAL-NERVOUS-SYSTEM; GROWTH-FACTOR-I; N-TERMINAL TRIPEPTIDE; NEUROTROPHIC FACTOR; MATRIX METALLOPROTEINASES; BRAIN-INJURY; INFARCT SIZE; ACUTE STROKE; MICROGLIAL ACTIVATION;
D O I：
10.3390/ijms23010014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Its increasing incidence has led stroke to be the second leading cause of death worldwide. Despite significant advances in recanalization strategies, patients are still at risk for ischemia/reperfusion injuries in this pathophysiology, in which neuroinflammation is significantly involved. Research has shown that in the acute phase, neuroinflammatory cascades lead to apoptosis, disruption of the blood-brain barrier, cerebral edema, and hemorrhagic transformation, while in later stages, these pathways support tissue repair and functional recovery. The present review discusses the various cell types and the mechanisms through which neuroinflammation contributes to parenchymal injury and tissue repair, as well as therapeutic attempts made in vitro, in animal experiments, and in clinical trials which target neuroinflammation, highlighting future therapeutic perspectives.
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页数：31
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