Persistence of yellow fever vaccine RNA in urine

被引：13

作者：

Martinez, Miguel J. ^{[1
,3
]}

Vilella, Anna ^{[1
,2
]}

Pumarola, Tomas ^{[1
,3
]}

Roldan, Montserrat ^{[2
]}

Sequera, Victor G. ^{[2
]}

Vera, Isabel ^{[2
]}

Hayes, Edward B. ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin, CRESIB, Barcelona Ctr Int Hlth Res, E-08036 Barcelona, Spain

[2] Hosp Clin Barcelona, Dept Prevent Med, Barcelona, Spain

[3] Hosp Clin Barcelona, Dept Clin Microbiol, Barcelona, Spain

来源：

VACCINE | 2011年 / 29卷 / 18期

关键词：

Yellow fever; 17D; Flavivirus; Persistence; Urine; Nucleic acid; NILE-VIRUS-INFECTION; GOLDEN-HAMSTER;

D O I：

10.1016/j.vaccine.2011.02.075

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To evaluate possible persistence of 17D yellow fever vaccine, we tested urine samples from 44 healthy recipients of yellow fever vaccine at varying times up to one year after vaccination. Urine samples from two vaccine recipients had detectable yellow fever virus RNA. The time since vaccination was reported as 21 days for one sample and 198 days for the other sample. These results suggest that yellow fever vaccine virus might persist for at least 6 months after vaccination in some people. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3374 / 3376

页数：3

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