Animal model of experimentally induced ectopic enchondral ossification in nude mice with xenograft of porcine epiphyseal cartilage

被引:2
作者
Berns, T
Quang, TH
Althoff, J
Quint, P
Richter, KD
机构
[1] WWU, Klin & Poliklin Allgemeine Chirurg, D-48149 Munster, Germany
[2] Univ Munster, Clin & Policlin Gen Surg, D-4400 Munster, Germany
[3] Univ Munster, Cent Expt Facil, D-4400 Munster, Germany
[4] Univ Munster, Inst Med Phys, D-4400 Munster, Germany
来源
JOURNAL OF MOLECULAR MEDICINE-JMM | 1999年 / 77卷 / 01期
关键词
nude mice; transplantation; epiphyseal growth plate; ossification; development of long bones;
D O I
10.1007/s001090050328
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In a specific animal model the induction of heterologous enchondral ossification was examined in long term follow-up. Physiologically normal and devitalized frozen porcine epiphyseal cartilage as a control group were transplanted as s.c. xenograft into athymic nude mice (nu/nu). 15 weeks after transplantation the porcine growth plate cartilage showed the development of viable cartilage tissue in the recipients, further differentiating to juvenile longe bone with epiphysis, diaphysis and growth plate. Porcine growth plate cartilage increased s.c. in the recipient nude mice, showing enchondral ossification without any physiological load, and finally an unexpected development towards complete juvenile long bone.
引用
收藏
页码:165 / 168
页数:4
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