Risperidone-induced topological alterations of anatomical brain network in first-episode drug-naive schizophrenia patients: a longitudinal diffusion tensor imaging study

被引:24
作者
Hu, M. [1 ,2 ,3 ,4 ]
Zong, X. [1 ]
Zheng, J. [5 ]
Mann, J. J. [2 ,3 ,4 ]
Li, Z. [1 ]
Pantazatos, S. P. [2 ,3 ]
Li, Y. [5 ]
Liao, Y. [1 ,6 ]
He, Y. [1 ]
Zhou, J. [1 ]
Sang, D. [7 ]
Zhao, H. [7 ]
Tang, J. [1 ,6 ]
Chen, H. [5 ]
Lv, L. [8 ,9 ]
Chen, X. [1 ,10 ,11 ,12 ]
机构
[1] Cent South Univ, Mental Hlth Inst, Xiangya Hosp 2, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[2] Columbia Univ, New York State Psychiat Inst, Div Mol Imaging & Neuropathol, 1051 Riverside Dr,Box 42, New York, NY 10032 USA
[3] Columbia Univ, Dept Psychiat, 1051 Riverside Dr,Box 42, New York, NY 10032 USA
[4] Columbia Univ, Dept Radiol, 1051 Riverside Dr,Box 42, New York, NY 10032 USA
[5] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China
[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci, Los Angeles, CA 90024 USA
[7] Xinxiang Med Univ, Henan Mental Hosp, Dept Radiol, Affiliated Hosp 2, Xinxiang 453002, Henan, Peoples R China
[8] Xinxiang Med Univ, Henan Mental Hosp, Dept Psychiat, Affiliated Hosp 2, Xinxiang 453002, Henan, Peoples R China
[9] Xinxiang Med Univ, Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China
[10] China Natl Clin Res Ctr Mental Hlth Disorders, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[11] Natl Technol Inst Psychiat, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[12] Key Lab Psychiat & Mental Hlth Hunan Prov, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
基金
中国国家自然科学基金; 美国国家卫生研究院;
关键词
First-episode schizophrenia; longitudinal studies; networks; schizophrenia; topology; white matter; WHITE-MATTER MICROSTRUCTURE; PREDICTS TREATMENT RESPONSE; ANTIPSYCHOTIC TREATMENT; MEDICATION; CONNECTIVITY; CORTEX; STATE; DYSFUNCTION; INTEGRITY; SYMPTOMS;
D O I
10.1017/S0033291716001380
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background It remains unclear whether the topological deficits of the white matter network documented in cross-sectional studies of chronic schizophrenia patients are due to chronic illness or to other factors such as antipsychotic treatment effects. To answer this question, we evaluated the white matter network in medication-naive first-episode schizophrenia patients (FESP) before and after a course of treatment. Method We performed a longitudinal diffusion tensor imaging study in 42 drug-naive FESP at baseline and then after 8 weeks of risperidone monotherapy, and compared them with 38 healthy volunteers. Graph theory was utilized to calculate the topological characteristics of brain anatomical network. Patients' clinical state was evaluated using the Positive and Negative Syndrome Scale (PANSS) before and after treatment. Results Pretreatment, patients had relatively intact overall topological organizations, and deficient nodal topological properties primarily in prefrontal gyrus and limbic system components such as the bilateral anterior and posterior cingulate. Treatment with risperidone normalized topological parameters in the limbic system, and the enhancement positively correlated with the reduction in PANSS-positive symptoms. Prefrontal topological impairments persisted following treatment and negative symptoms did not improve. Conclusions During the early phase of antipsychotic medication treatment there are region-specific alterations in white matter topological measures. Limbic white matter topological dysfunction improves with positive symptom reduction. Prefrontal deficits and negative symptoms are unresponsive to medication intervention, and prefrontal deficits are potential trait biomarkers and targets for negative symptom treatment development.
引用
收藏
页码:2549 / 2560
页数:12
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