Polyoxygenated steroids from the gorgonian Isis hippuris

被引：40
作者：
Chao, CH
Huang, LF
Yang, YL
Su, JH
Wang, GH
Chiang, MY
Wu, YC
Dai, CF
Sheu, JH [1 ]
机构：
[1] Natl Sun Yat Sen Univ, Dept Marine Resources, Kaohsiung 804, Taiwan
[2] Hsing Kuo Univ, Ctr Gen Educ, Tainan 709, Taiwan
[3] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan
[4] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
[5] Natl Taiwan Univ, Inst Oceanog, Taipei 106, Taiwan
来源：
JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 06期
关键词：
D O I：
10.1021/np050033y
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eleven new hippuristanols (1-4, 7-9, and 11-14), along with eight known metabolites (5, 6, 10, and 15-19), have been isolated from the gorgonian coral Isis hippuris. Single-crystal X-ray diffraction analyses supported the structure elucidation of known steroids 5 and 10. The absolute structures of hippuristanols were established by application of modified Mosher's method on 19. Compounds 14-19 have been found to exhibit significant cytotoxicity against several cancer cell lines.
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页码：880 / 885
页数：6
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