The effects of melamine with or without cyanuric acid on immune function in ovalbumin-sensitized mice

被引：13

作者：

Yin, Rong H. ^{[1
]}

Dong, Qiao ^{[1
]}

Li, Hua S. ^{[1
]}

Yuan, Jing ^{[1
]}

Li, Xi T. ^{[1
]}

Yin, Rong L. ^{[2
]}

Li, Wen ^{[1
]}

Wang, Wen C. ^{[1
]}

Liu, Bao S. ^{[1
]}

Han, Xiao H. ^{[1
]}

Wang, Ren F. ^{[1
]}

Wang, Xin ^{[1
]}

Bai, Wen L. ^{[1
]}

机构：

[1] Shenyang Agr Univ, Coll Anim Sci & Vet Med, Key Lab Zoonosis Liaoning Prov, Shenyang 110866, Liaoning, Peoples R China

[2] Res Acad Anim Husb & Vet Med Sci Jilin Prov, Changchun 130062, Jilin, Peoples R China

来源：

RESEARCH IN VETERINARY SCIENCE | 2017年 / 114卷

基金：

中国国家自然科学基金;

关键词：

Melamine; Cyanuric acid; Immune function; Ovalbumin; Mouse; DENDRITIC CELLS; LUNG-CANCER; CD40; TOXICITY; ABSENCE; RATS; LYMPHOCYTES; EXPRESSION; EXPOSURE; LIGAND;

D O I：

10.1016/j.rvsc.2017.05.015

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Melamine is commonly used in the chemical industry, and it has been found to exist on food processing equipment and utensils. Previous investigations suggested that melamine alone or its combination with cyanuric acid appears to be toxic to immune system in animals. The objective of this study is to investigate the potential effects of melamine with or without cyanuric acid on immune function in ovalbumin-sensitized mice. Our data indicated that melamine-related administration caused a significant decreasing in the content of IL-4 in mice in comparison to negative control group. Significant increasing in the content of histamine (HIS) was recorded in almost all treated groups. The co-administration of melamine and cyanuric acid with high dose (each at 16 mg kg(-1)2 d(-1)) led to a significantly lower contents of IL-10, IL-16 and monocyte chemoattractant protein-1 (MCP-1) in mouse serum in comparison to negative control group. Moreover, our data indicated that the number of Th1 and Th2 cells, and the ratio of Th1/Th2 spleen lymphocytes were significantly changed after treatment. Also, our results demonstrated that the profiles of both CD40 and CD40L were significantly altered in spleen lymphocytes after treatment.

引用

页码：254 / 261

页数：8

共 38 条

[1]

Abd-Elhakim Y.M., 2016, J IMMUNOTOXICOL, V2016, P1

[2] Respiratory Syncytial Virus Reverses Airway Hyperresponsiveness to Methacholine in Ovalbumin-Sensitized Mice [J].

Aeffner, Famke ;

Davis, Ian C. .

PLOS ONE, 2012, 7 (10)

[3] Prenatal melamine exposure induces impairments of spatial cognition and hippocampal synaptic plasticity in male adolescent rats [J].

An, Lei ;

Zhang, Tao .

REPRODUCTIVE TOXICOLOGY, 2014, 49 :78-85

[4] Melamine induced cognitive impairment associated with oxidative damage in rat's hippocampus [J].

An, Lei ;

Li, Zhanyong ;

Yang, Zhuo ;

Zhang, Tao .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2012, 102 (02) :196-202

[5] Simultaneous determination and confirmation of melamine and cyanuric acid in animal feed by zwitterionic hydrophilic interaction chromatography and tandem mass spectrometry [J].

不详 .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2008, 22 (22) :3624-3632

[6] The toxic effect of a mixture of melamine and cyanuric acid on the gastrointestinal tract and liver in mice [J].

Chang, Lingling ;

Yue, Zhuo ;

She, Ruiping ;

Sun, Yanyan ;

Zhu, Jinfeng .

RESEARCH IN VETERINARY SCIENCE, 2015, 102 :234-237

[7] Acute testicular toxicity induced by melamine alone or a mixture of melamine and cyanuric acid in mice [J].

Chang, Lingling ;

She, Ruiping ;

Ma, Longhuan ;

You, Hua ;

Hu, Fengjiao ;

Wang, Tongtong ;

Ding, Xiao ;

Guo, Zhaojie ;

Soomro, Majid Hussain .

REPRODUCTIVE TOXICOLOGY, 2014, 46 :1-11

[8]

Chechlinska M, 2004, CELL MOL BIOL LETT, V9, P69

[9] Non-lethal viral challenge of influenza haemagglutinin and nucleoprotein DNA vaccinated mice results in reduced viral replication [J].

Cox, RJ ;

Mykkeltvedt, E ;

Robertson, J ;

Haaheim, LR .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2002, 55 (01) :14-23

[10]

CRUIKSHANK W, 1982, J IMMUNOL, V128, P2569

← 1 2 3 4 →