(22E,24S)-24-Propylcholest-5en-3α-acetate: A New Steroid from the Stembark Aglaia angustifolia (Miq.) (Meliaceae)

被引：5

作者：

Hutagaol, Ricson P. ^{[1
,2
]}

Harneti, Desi ^{[2
]}

Hidayat, Ace T. ^{[2
,3
]}

Nurlelasari, Nurlelasari ^{[2
]}

Maharani, Rani ^{[2
,3
]}

Katja, Dewa Gede ^{[4
]}

Supratman, Unang ^{[2
,3
]}

Awang, Khalijah ^{[5
]}

Shiono, Yoshihito ^{[6
]}

机构：

[1] Nusa Bangsa Univ, Fac Math & Nat Sci, Dept Chem, Bogor 16166, West Java, Indonesia

[2] Univ Padjadjaran, Fac Math & Nat Sci, Dept Chem, Jatinangor 45363, West Java, Indonesia

[3] Univ Padjadjaran, Cent Lab, Jatinangor 45363, West Java, Indonesia

[4] Univ Sam Ratulangi, Fac Math & Nat Sci, Dept Chem, Kampus Bahu, Manado 95115, North Sulawesi, Indonesia

[5] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 59100, Malaysia

[6] Yamagata Univ, Fac Agr, Dept Food Life & Environm Sci, Tsuruoka, Yamagata 9978555, Japan

来源：

MOLBANK | 2020年 / 2020卷 / 01期

关键词：

Aglaia angustifolia; Meliaceae; MCF-7; propylcholesterol; BARK;

D O I：

10.3390/M1112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new propylcholesterol-type steroid, namely (22E,24S)-24-propylcholest-5en-3 alpha-acetate (1), has been isolated from the stembark of Aglaia angustifolia (Miq.). The structure of 1 was determined on the basis of spectroscopic data including 1D- and 2D-NMR as well as high resolution mass spectroscopy analysis. Compound 1 showed weak activity against the MCF-7 breast cancer cell line.

引用

页数：6

共 19 条

[1]

Farabi Kindi, 2017, Chiang Mai University Journal of Natural Sciences, V16, P293, DOI [10.12982/CMUJNS.2017.0024, 10.12982/cmujns.2017.0024]

[2] New Cytotoxic Pregnane-type Steroid from the Stem Bark of Aglaia elliptica (Meliaceae) [J].

Farabi, Kindi ;

Harneti, Desi ;

Nurlelasari ;

Maharani, Rani ;

Hidayat, Ace Tatang ;

Awang, Khalijah ;

Supratman, Unang ;

Shiono, Yoshihito .

RECORDS OF NATURAL PRODUCTS, 2018, 12 (02) :121-127

[3] New cytotoxic protolimonoids from the stem bark of Aglaia argentea (Meliaceae) [J].

Farabi, Kindi ;

Harneti, Desi ;

Nurlelasari ;

Maharani, Rani ;

Hidayat, Ace Tatang ;

Awang, Khalijah ;

Supratman, Unang ;

Shiono, Yoshihito .

PHYTOCHEMISTRY LETTERS, 2017, 21 :211-215

[4] Sterol composition of Aureoumbra lagunensis, the Texas brown tide alga [J].

Giner, JL ;

Li, XY ;

Boyer, GL .

PHYTOCHEMISTRY, 2001, 57 (05) :787-789

[5] Stereospecific synthesis of 24-propylcholesterol isolated from the Texas brown tide [J].

Giner, JL ;

Li, XY .

TETRAHEDRON, 2000, 56 (49) :9575-9580

[6] TNFAIP8 Overexpression: Clinical Relevance to Esophageal Squamous Cell Carcinoma [J].

Hadisaputri, Yuni Elsa ;

Miyazaki, Tatsuya ;

Suzuki, Shigemasa ;

Yokobori, Takehiko ;

Kobayashi, Tsutomu ;

Tanaka, Naritaka ;

Inose, Takanori ;

Sohda, Makoto ;

Kuwano, Hiroyuki .

ANNALS OF SURGICAL ONCOLOGY, 2012, 19 :S589-S596

[7] Cytotoxic constituents from the bark of Aglaia eximia (Meliaceae) [J].

Harneti, Desi ;

Supriadin, Asep ;

Ulfah, Mariam ;

Safari, Agus ;

Supratman, Unang ;

Awang, Khalijah ;

Hayashi, Hideo .

PHYTOCHEMISTRY LETTERS, 2014, 8 :28-31

[8] Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae) [J].

Harneti, Desi ;

Tjokronegoro, Roekmiati ;

Safari, Agus ;

Supratman, Unang ;

Loong, Xe-Min ;

Mukhtar, Mat Ropi ;

Mohamad, Khalit ;

Awang, Khalijah ;

Hayashi, Hideo .

PHYTOCHEMISTRY LETTERS, 2012, 5 (03) :496-499

[9]

Heyne K., 1982, USEFUL INDONESIAN PL, P1029

[10]

Hidayat Ace Tatang, 2017, Natural Product Sciences, V23, P291, DOI 10.20307/nps.2017.23.4.291

← 1 2 →