Cascade polycyclisations in natural product synthesis

被引：79

作者：

Anderson, Edward A. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

EPOXIDE-OPENING CASCADES; PALLADIUM-CATALYZED OLIGOCYCLIZATIONS; LADDER POLYETHER SYNTHESIS; ASYMMETRIC-SYNTHESIS; BIS-SPIROACETAL; TETHER LENGTHS; METHYL-ESTER; ABUDINOL-B; CYCLIZATION; SPIRASTRELLOLIDE;

D O I：

10.1039/c1ob05212h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient, stereocontrolled construction of polycyclic ring systems has long presented a formidable challenge to synthetic chemists. Cascade reactions offer a 'quick fix'-building multiple rings in a single step-and often dramatically shorten a synthetic route. In this Emerging Area article, a selection of the most recent and impressive examples of applications of this tactic to natural product synthesis are discussed, which demonstrate the ambition and achievements of the modern synthetic chemist.

引用

页码：3997 / 4006

页数：10

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