Toxicity of Metformin and Hypoglycemic Therapies

被引：25
作者：
Akhter, Muhammad S. [1 ]
Uppal, Priyasha [2 ]
机构：
[1] Mt Sinai Beth Israel Icahn Sch Med Mt Sinai, First Ave & 16th St, New York, NY 10003 USA
[2] Mt Sinai Beth Israel, New York, NY USA
来源：
ADVANCES IN CHRONIC KIDNEY DISEASE | 2020年 / 27卷 / 01期
关键词：
Diabetes mellitus; Chronic kidney disease; Safety; Toxicity; Adverse effects; ACTIVATED PROTEIN-KINASE; DIPEPTIDYL PEPTIDASE-4 INHIBITION; PEPTIDE-1 RECEPTOR AGONISTS; TYPE-2; DIABETES-MELLITUS; BLOOD-GLUCOSE CONTROL; CARDIOVASCULAR OUTCOMES; LACTIC-ACIDOSIS; RENAL-FUNCTION; DOUBLE-BLIND; GLYCEMIC CONTROL;
D O I：
10.1053/j.ackd.2019.08.004
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Metformin along with other antidiabetic medications provide benefit to patients in the treatment of type 2 diabetes mellitus, but caution is advised in certain scenarios to avoid toxicity in kidney disease. Renal dosing, monitoring of kidney function, and evaluating the risk of developing serious side effects are warranted with some agents. The available literature with regard to incidence of adverse events and toxicity of hypoglycemic therapies is reviewed. (C) 2019 by the National Kidney Foundation, Inc. All rights reserved.
引用
收藏
页码：18 / 30
页数：13
相关论文
共 135 条
[1]   Variations in tissue selectivity amongst insulin secretagogues: a systematic review [J].
Abdelmoneim, A. S. ;
Hasenbank, S. E. ;
Seubert, J. M. ;
Brocks, D. R. ;
Light, P. E. ;
Simpson, S. H. .
DIABETES OBESITY & METABOLISM, 2012, 14 (02) :130-138
[2]   Guidelines Newer agents for blood glucose control in type 2 diabetes: summary of NICE guidance [J].
Adler, Amanda I. ;
Shaw, Elizabeth J. ;
Stokes, Tim ;
Ruiz, Francis .
BMJ-BRITISH MEDICAL JOURNAL, 2009, 338
[3]   Metformin: an old but still the best treatment for type 2 diabetes [J].
Aguayo Rojas, Lilian Beatriz ;
Gomes, Marilia Brito .
DIABETOLOGY & METABOLIC SYNDROME, 2013, 5
[4]   Counterpoint: A Diabetes Outcome Progression Trial (ADOPT): Good for sulfonylureas? [J].
Al-Ozairi, Ebaa ;
Sibal, Latika ;
Home, Philip .
DIABETES CARE, 2007, 30 (06) :1677-1680
[5]   AMP-activated Protein Kinase as a Drug Target in Chronic Kidney Disease [J].
Allouch, Soumaya ;
Munusamy, Shankar .
CURRENT DRUG TARGETS, 2018, 19 (06) :709-720
[6]  
[Anonymous], 2017, STEGL ERT
[7]  
[Anonymous], 2018, JARD EMP
[8]  
[Anonymous], 2018, INV CAN
[9]  
[Anonymous], 1975, DIABETES, V24, P65
[10]  
[Anonymous], 2018, DIABETES CARE, DOI DOI 10.1007/S11548-018-1807-61
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