The Dual Effect of Copper and Gamma Irradiation on Chronic Wound Healing of Nanobioactive Glass

被引：10

作者：

Ahmed, Manar M. ^{[1
]}

Abd-Allah, Wesam M. ^{[2
]}

Omar, Areg E. ^{[3
]}

Soliman, Ahmed A. F. ^{[4
]}

机构：

[1] Natl Res Ctr, Glass Res Dept, 33 El Bohooth St, Cairo 12622, Egypt

[2] Egyptian Atom Energy Author EAEA, Natl Ctr Radiat Res & Technol NCRRT, Radiat Chem Dept, POB 8029, Cairo 11371, Egypt

[3] Al Azhar Univ, Fac Sci, Dept Phys, Girls Branch, Cairo, Egypt

[4] Natl Res Ctr, Dept Pharmacognosy, Giza 12622, Egypt

来源：

JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS | 2020年 / 30卷 / 09期

关键词：

Nanobioactive glass; Sol-gel; Gamma ray; CuO; Wound healing; Cytoxcity; FIBROBLAST-GROWTH-FACTOR; BIOACTIVE GLASS; IONS; CYTOTOXICITY; ANGIOGENESIS; NANOPARTICLE; SCAFFOLDS; DELIVERY;

D O I：

10.1007/s10904-020-01501-0

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Nano bioactive glasses in the system; 70 SiO2-10 P2O5-(20-x) CaO-xCuO (x = 0, 3 and 5% mol%), were synthesized by the rapid alkali sol-gel method. The dual effect of incorporating 0, 3, and 5 mol% of CuO (replacing CaO) and gamma irradiation on nanobioactive glasses structure were studied. The bioactivity, cytotoxicity and promotion in wound healing of fibroblast cells (BJ-1) were studied. The results showed that the unirradiated and irradiated samples were able to form hydroxyapatite layer on their surfaces in SBF after 30 days. Scratch-wound healing assay also, indicated that the samples which incorporating 3 mol% of CuO with or without gamma irradiation had the highest wound closure rate (99.1%, and 98.1%, respectively). The result of cytotoxic assay demonstrated that 100 mu g/mL of 0, 3 mol% of CuO before and after gamma irradiation showed non-significant decrease (p > 0.05) in the mean viability percentage towards BJ.1 cells. Therefore, these compositions could be suitable for wound healing applications.

引用

页码：3646 / 3657

页数：12

共 47 条

[1] Compatibility and Bone Bonding Efficiency of Gamma Irradiated Hench's Bioglass [J].

Abdelghany, A. M. ;

ElBatal, H. A. ;

Okasha, Aly ;

Ramadan, R. M. ;

Wassel, A. R. ;

Menazea, A. A. .

SILICON, 2018, 10 (04) :1533-1541

[2]

Banigo A.T., 2019, Journal of Chemical and Pharmaceutical Research, V11, P1

[3] Sol-gel synthesis and in vitro bioactivity of copper and zinc-doped silicate bioactive glasses and glass-ceramics [J].

Bejarano, Julian ;

Caviedes, Pablo ;

Palza, Humberto .

BIOMEDICAL MATERIALS, 2015, 10 (02)

[4] Use of radiation in biomaterials science [J].

Benson, RS .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2002, 191 :752-757

[5] SiO2-P2O5-CaO Glasses and Glass-Ceramics with and without ZnO: Relationships among Composition, Microstructure, and Bioactivity [J].

Bini, M. ;

Grandi, S. ;

Capsoni, D. ;

Mustarelli, P. ;

Saino, E. ;

Visai, L. .

JOURNAL OF PHYSICAL CHEMISTRY C, 2009, 113 (20) :8821-8828

[6]

Cheng J.L., 2020, RESULTS MATH, V5, DOI [10.1016/j.rinma.2019.100051, DOI 10.1016/J.RINMA.2019.100051]

[7] Development, characterization, and in vitro bioactivity studies of sol-gel bioactive glass/poly(L-lactide) nanocomposite scaffolds [J].

El-Kady, Abeer M. ;

Ali, Ashraf F. ;

Farag, Mohmmad M. .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2010, 30 (01) :120-131

[8] Scaffold Techniques and Designs in Tissue Engineering Functions and Purposes: A Review [J].

Eltom, Abdalla ;

Zhong, Gaoyan ;

Muhammad, Ameen .

ADVANCES IN MATERIALS SCIENCE AND ENGINEERING, 2019, 2019

[9] Effect of gamma irradiation on drug releasing from nano-bioactive glass [J].

Farag, M. M. ;

Abd-Allah, W. M. ;

Ibrahim, A. M. .

DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2015, 5 (01) :63-73

[10] Effect of Gamma Irradiation on Structural and Optical Investigations of Borosilicate Glass Doped Yttrium Oxide [J].

Fayad, A. M. ;

Abd-Allah, W. M. ;

Moustafa, F. A. .

SILICON, 2018, 10 (03) :799-809

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